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chromosomal mutation

   Also found in: Encyclopedia, Wikipedia, Hutchinson 0.02 sec.
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.chromosomal mutation - (genetics) any event that changes genetic structure; any alteration in the inherited nucleic acid sequence of the genotype of an organism
genetic science, genetics - the branch of biology that studies heredity and variation in organisms
alteration, change, modification - an event that occurs when something passes from one state or phase to another; "the change was intended to increase sales"; "this storm is certainly a change for the worse"; "the neighborhood had undergone few modifications since his last visit years ago"
deletion - (genetics) the loss or absence of one or more nucleotides from a chromosome
inversion - (genetics) a kind of mutation in which the order of the genes in a section of a chromosome is reversed
transposition - (genetics) a kind of mutation in which a chromosomal segment is transfered to a new position on the same or another chromosome
mutagenesis - an event capable of causing a mutation
gene mutation, point mutation - (genetics) a mutation due to an intramolecular reorganization of a gene
reversion - (genetics) a return to a normal phenotype (usually resulting from a second mutation)
saltation - (genetics) a mutation that drastically changes the phenotype of an organism or species


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To the Editor: In pneumococci, resistance to fluoroquinolones is associated with chromosomal mutations in the quinolone-resistance-determining regions (QRDR) of type II topoisomerase enzymes, predominantly gyrA and parC.
Because most ROS are short-lived and can only diffuse short distances in cells, it is still not clear how these radicals reach the nucleus to cause gene and chromosomal mutation (54,55).
The Genzyme team speculates that measuring children's levels of mature CFTR might offer a simpler diagnostic test than the current searches for chromosomal mutations.
 
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