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chromosomal mutation |
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To the Editor: In pneumococci, resistance to fluoroquinolones is associated with chromosomal mutations in the quinolone-resistance-determining regions (QRDR) of type II topoisomerase enzymes, predominantly gyrA and parC. Because most ROS are short-lived and can only diffuse short distances in cells, it is still not clear how these radicals reach the nucleus to cause gene and chromosomal mutation (54,55). The Genzyme team speculates that measuring children's levels of mature CFTR might offer a simpler diagnostic test than the current searches for chromosomal mutations. |
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