Patients with FCS are unable to effectively clear lipid particles called chylomicrons
, and as a result, have extremely high levels of triglycerides, putting them at risk of potentially life-threatening pancreatitis.
Within the digestive tract, oleic acid promotes the formation of chylomicrons
, which are transport molecules that carry carotenoids up into the body.
, comprising 85-90% TG and containing apolipoprotein B (apo B)-48 (apoB48), apolipoprotein Ai (apoAi) and apolipoprotein Aiv (apoAiv), are produced in enterocytes, traverse the thoracic duct and ultimately reach the systemic circulation.
are processed by the liver and L and Z are secreted from here in association with low density and high density lipoproteins, known as LDLs and HDLs respectively.
In avian species, most fatty acids are synthesized in the liver and transported via low-density lipoproteins or chylomicrons
for storage in adipose tissues as triglycerides (Hermier, 1997).
In humans, based on experiments indicated that the combination of fat and alcohol has a positive effect on plasma triglyceride concentration, because alcohol can suppress colon cleansing from chylomicrons
derivatives [12, 13].
Mechanistically, these findings are easy to understand, as lipoprotein lipase hydrolyses triglycerides contained in chylomicrons
and very-low-density lipoprotein (17).
The difference between this type of interference and other types, such as hemolysis or icterus, is that lipemic specimens consist of suspended particles of VLDL (very low density lipoproteins) and chylomicrons
, causing varying degrees of turbidity.
Chyle consists of lymph of intestinal origin, which is a milky and opalescent fluid rich in lymphocytes, protein, triglycerides and chylomicrons
This area of posterior parietal pericardial dissection around the paired pulmonary veins could allow a path of ingress of posterior mediastinal, peribronchial lymph to the pericardial space; absorbed oral fat in the form of chylomicrons
could then enter into the pericardial space in this fashion.
Another shorter form, apoB48, is the structural protein of chylomicrons
and is synthesized in the intestine.
The method is standardised against the reference beta quantification method and Roche data indicates little interference from high levels of VLDL, chylomicrons