-resistant sublines (SW480) were selected by double subcloning using the limiting dilution method from cultures continuously exposed to increasing concentrations of cisplatin
Eight patients with advanced biliary tract cancer received Acelarin and cisplatin
on days one and eight of a three-week cycle.
Using a highly sensitive technique to measure and map cisplatin
in mouse and human inner ear tissues, researchers found that forms of cisplatin
build up in the inner ear.
The antioxidant effect of p-Coumaric acid was evaluated against brain damage induced by cisplatin
A single dose of cisplatin
10mg/kg was given as I/P injection to the toxic group.
Concurrent chemo-RT included 60–66 Gray (Gy) of RT with weekly cisplatin
and was similar in both the arms.
In mice the addition of 1 [micro]L of fish oil to cisplatin
was sufficient to induce chemoresistance, to the degree that treatment no longer inhibited tumor growth.
and 5-fluorouracil (FU) with or without other drugs in oral cancer remain to be the most preferred regimen.
is an effective and widely used as chemotherapeutic agent and also as a radiosensitiser in radiotherapy.
Platinum coordination compounds have been successfully applied in cancer chemotherapy for more than 25years since the introduction of the parent compound for this class of antitumor agents, namely, cis-[diamminedichloro-platinum(II)] (1) known as cisplatin
(Fig 1a & b).
Chemotherapy is one of the most common treatments (2, 3) and cisplatin
(CP) as a member of the platinum drugs is used to treat testicular, ovarian, breast, lung, and bladder cancers (4).
inhibited HaCaT cell proliferation and migration.