Because such dose-dependent changes in the electrical activity of the heart can lead to abnormal heart rhythms, including the potentially fatal Torsade de Pointes, and in the absence of evidence demonstrating that citalopram
at doses higher than 40 mg per day is beneficial in the treatment of depression, the FDA determined that citalopram
should no longer be used at doses above 40 mg per day and that it should not be used at all in patients with congenital long QT syndrome.
In 24-week follow-up of a previously reported 12-week study, patients aged 40 years and older with schizophrenia or schizoaffective disorder whose regular antipsychotic therapy was augmented with the SSRI citalopram
(Celexa) maintained a significant decrease in suicidal ideation scale scores, compared with similar patients on an antipsychotic and placebo, reported Dr.
These include a Scandinavian-based registry study of 375 women exposed to citalopram
(Celexa) in the first trimester, which failed to indict SSRI as a teratogen.
a subsidiary of Alpharma, has received approval from the United States Food and Drug Administration ("FDA") for citalopram
hydrobromide tablets,10 mg, 20 mg and 40 mg.
In that trial, known as the TRIDMAC (TM) trial, patients whose continued citalopram
treatment was augmented with racemic mecamylamine showed greater improvement on symptoms of depression than patients who received continued citalopram
treatment and placebo.
Martin Schaefer conducted an open-label prospective study examining the efficacy of citalopram
CHICAGO -- Citalopram
may be an effective option for reducing hot flashes, having performed twice as well as placebo in a randomized, placebo-controlled phase III trial conducted by the North Central Cancer Treatment Group.
A total of 228 adverse events associated with the use of citalopram
(Celexa) during pregnancy has been reported to the Food and Drug Administration's Adverse Event Reporting System since the drug was approved in 1998, J.
a technology-based specialty pharmaceutical and drug delivery company with a growing branded and generic product line in Europe, announced today that three of its Spanish subsidiaries (Laboratorios Belmac, Davur and Rimafar) have received approval to market 10mg, 20mg and 40mg branded and generic versions of citalopram
In a Phase 2 trial in patients who did not respond adequately to first-line treatment with citalopram
hydrobromide that Targacept completed in 2006, patients whose citalopram
regimen was augmented with mecamylamine showed greater improvement on symptoms of depression and irritability than patients who received citalopram
and a placebo.
The review looked at the following drugs: bupropion, citalopram
(Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine, fluvoxamine (Luvox), milnacipran, mirtazapine (Remeron), paroxetine (Paxil), reboxetine, sertraline (Zoloft), and venlafaxine (Effexor) (Lancet 2009 [doi: 10.
BALTIMORE -- Treatment with the selective serotonin reuptake inhibitor citalopram
of individuals who have high levels of hostility not only reduces hostility but improves the cardiovascular risk factors that make up metabolic syndrome, data presented at the annual meeting of the American Psychosomatic Society show.