clavulanic acid


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clav·u·lan·ic acid

 (klăv′yo͝o-lăn′ĭk)
n.
A compound, C8H9NO5, originally obtained from the bacterium Streptomyces clavuligerus, that inhibits action of the enzyme beta-lactamase, thus counteracting bacterial resistance to beta-lactam antibiotics. It is used in combination with antibiotics such as amoxicillin to treat infections caused by antibiotic-resistant bacteria.

[New Latin clāvul(igerus), specific epithet (from clāvula, spore, diminutive of Latin clāva, club) + -an(e) + -ic.]
References in periodicals archive ?
Contract awarded for amoxicillin + clavulanic acid, powder for suspension 250 mg + 62.
We treated women attending the public clinic according to Essential Drugs List (EDL) recommendations with either a single 500 mg dose of ciprofloxacin (for non-pregnant participants) or with a 1-week course of 250 mg amoxicillin/125 mg clavulanic acid given 8-hourly (for pregnant participants).
Similarly, the content of Clavulanic Acid in the freshly prepared sample was 20 per cent less than the IP 2007 limit.
27 against these strains, whereas ceftazidime plus clavulanic acid or quercetin did not exhibit synergy.
The 10 isolates that showed a phenotypic ESBL profile were verified by clavulanic acid inhibition in double mixture discs with cefpodoxime, and 2 ESBL strains were found, one strain in masked booby and one strain in christmas shearwater.
5 2 Meropenem 3 29 16 1 3 2 Doxycycline ([dagger]) -- 13 19 18 3 1 Ceftazidime ([dagger]) -- 2 0 18 25 7 Amoxicillin/ -- 1 0 13 30 7 clavulanic acid Chloramphenicol -- -- -- -- 1 1 0.
g): cefotaxime (CTX) (30), cefotaxime + clavulanic acid (10), cefatzidime (CAZ) (30), and ceftazidime +clavulanic acid (10).
The results show significant association between class 1 integron presence and antimicrobial resistance towards, Amoxicillin/ Clavulanic Acid (OR 2.
E-test strips are drug impregnated strips that contain a gradient of antibiotic on one end and ceftazidime plus clavulanic acid on the other end.
Dragon is the third largest 7-ACA producer and the first manufacturer and market leader of clavulanic acid products in China.
A screening test is then performed with clavulanic acid.