clavulanic acid


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clav·u·lan·ic acid

 (klăv′yo͝o-lăn′ĭk)
n.
A compound, C8H9NO5, originally obtained from the bacterium Streptomyces clavuligerus, that inhibits action of the enzyme beta-lactamase, thus counteracting bacterial resistance to beta-lactam antibiotics. It is used in combination with antibiotics such as amoxicillin to treat infections caused by antibiotic-resistant bacteria.

[New Latin clāvul(igerus), specific epithet (from clāvula, spore, diminutive of Latin clāva, club) + -an(e) + -ic.]
References in periodicals archive ?
The son and daughter had had a sore throat 9 days before onset of illness in the mother and were treated empirically by their general practitioner with amoxicillin/ clavulanic acid (1 g 2x/d for 6 d).
For Gram-positive organisms ampicillin, cefoxitin, cefixime, azithromycin, ofloxacin, amikacin, clindamycin, amoxicillin + clavulanic acid, vancomycin, and linezolid were used.
The antibiotic sensitivity according to CLSI guidelines showed resistant to Cephalexin (79%), Cefoxitin (70%), Norfloxacin (70%), Nitrofurantoin (67%), Ampicillin (63%), Amoxyclav (61%), Cotrimoxazole (62%), Ciprofloxacin (70%), Ceftazidime (69%), Cefotaxime (67%), Amikacin (60%), Gentamicin (69%), Tetracycline (60%), Piperacillin/tazobactam (50%), Cefoperazone-sulbactam (51%), Ceftazidime Clavulanic acid (53%), Imipenem (2%).
All had an abdominal CT scan and received intravenous antibiotics, either an initial infusion of 1 g of amoxicillin per 125 mg of clavulanic acid, or, in the case of those with a penicillin allergy, ciprofloxacin 200 mg and metronidazole 500 mg (Ann.
coli isolates, 82 were phenotypically detected as ESBL producers by standard cefotaxime / clavulanic acid and ceftazidime / clavulanic acid disc diffusion tests.
Similarly, the content of Clavulanic Acid in the freshly prepared sample was 20 per cent less than the IP 2007 limit.
1,2) The ESBL are plasmid-mediated enzymes with the capability to hydrolyze and inactivate broad spectrum of [beta]-Lactam antimicrobials, including third-generation cephalosporins, penicillins and aztreonam; but are inhibited by clavulanic acid.
The 10 isolates that showed a phenotypic ESBL profile were verified by clavulanic acid inhibition in double mixture discs with cefpodoxime, and 2 ESBL strains were found, one strain in masked booby and one strain in christmas shearwater.
CHICAGO - Moxifloxacin works as well as the combination of amoxicillin and clavulanic acid in the treatment of acute exacerbations of complicated chronic obstructive pulmonary disease, new data show.
Ceftazidime, methicillin, ampicillin, amoxicillin, cloxacillin, penicillin G (benzylpenicillin), penicillinase ([beta]-lactamase) and clavulanic acid were obtained from Sigma (Sigma-Aldrich, UK).