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cleave 1

v. cleft (klĕft) or cleaved or clove (klōv), cleft or cleaved or clo·ven (klō′vən), cleav·ing, cleaves
1. To split with a sharp instrument. See Synonyms at tear1.
2. To make or accomplish by or as if by cutting: cleave a path through the ice.
3. To pierce or penetrate: The wings cleaved the foggy air.
4. Chemistry To split (a complex molecule) into simpler molecules.
1. To split or be capable or splitting, especially along a natural line of division: Certain brittle woods cleave easily.
2. To penetrate or pass through something, such as water or air.

[Middle English cleven, from Old English clēofan; see gleubh- in Indo-European roots.]

cleav′a·ble adj.

cleave 2

intr.v. cleaved, cleav·ing, cleaves
1. To adhere, cling, or stick fast.
2. To be faithful: cleave to one's principles.

[Middle English cleven, from Old English cleofian.]


(ˈkli və bəl)

capable of being split.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.cleavable - capable of being cleaved
divisible - capable of being or liable to be divided or separated; "even numbers are divisible by two"; "the Americans fought a bloody war to prove that their nation is not divisible"
References in periodicals archive ?
Whereas the multiple basic amino acids at the HA0 cleavage sites of HPAI viruses, either as a result of insertion or substitution (2-4), allows the HA0 precursor to be cleavable by ubiquitous host proteases (5).
MCIT's ADC platform technology is based on unique multivalent, cleavable linkers that allow tethered drugs to be released intracellularly or extracellularly upon binding of the antibody to the target cell.
In the first step a suitable protein, treated with reagents that provide reactive functional groups, is immobilized on a solid support via a cleavable linker.
The predicted protein does not seem to have cleavable signal sequence, but it does have a predicted transmembrane segment and a cysteine/lysine-rich domain (61).
Cell death results from stabilization of cleavable complexes formed between topoisomerase I and DNA during DNA replication, transcription, and repair (14-17).
These unique ADCs are designed to release drugs in their native form via biodegradation of the novel cleavable, multi-valent linker and tether after the ADC enters the cell.
55 Pipeline ADCs Using Protease Cleavable Peptide Linker Table 4.
The critical role of cleavable linkers for minor groove binding alkylating agent (MGBA) based antibody-drug conjugates (Abstract #1722)