clofazimine


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Related to clofazimine: dapsone
Translations

clofazimine

n clofazimina
References in periodicals archive ?
According to multivariate linear regression, use of clofazimine was significantly associated (p<0.
High dose clofazimine is often used as a steroid-sparing agent.
Treatment included rifampin, Dapsone, clofazimine, and prednisone.
Clofazimine is given with corticosteroids in every case, starting with 100 mgs three times a day, tapering to 100 mgs after every 12 weeks.
To the Editor: Since the initiation of multidrug therapy for leprosy (Hansen disease) in the 1980s by using rifampin, dapsone, and clofazimine, resistance to rifampin and dapsone has been observed worldwide and is still prevalent (1,2).
Dapsone, rifampin and clofazimine were introduced and the patient's condition improved the following weeks with discoloration of skin lesions and defervescence.
The patient was treated with rifampicin 450 mg/day, isoniazid 225 mg/day, pyrazinamide 1200 mg/day and streptomycin 75mg/day, in addition to dapsone 100mg/day and clofazimine 50 mg/day along with a monthly supervised dose of dapsone 100 mg, clofazimine 300 mg and rifampicin 150 mg for first 2 months.
The isolate was susceptible to all antimicrobial drugs tested in vitro, including amikacin, azithromycin, clarithromycin, ciprofloxacin, clofazimine, ethambutol, isoniazid, ofloxacin, rifabutin, rifampin, sparfloxacin, and streptomycin (3).
Thereafter treatment for leprosy was restarted with supervised monthly ofloxacin 400 mg, clofazimine 300 mg and rifampin 600 mg, and daily 400 mg ofloxacin and 50 mg clofazimine.
Since the 2004 US Food and Drug Administration designation of clofazimine as an investigational drug, any patients with multibacillary disease are likely to have been reported so they would be able to receive the recommended MDT, although paucibacillary disease may be underreported.
WHO has introduced multidrug therapy for the treatment involving Rifampicin, Dapsone and Clofazimine.
Because of the multibacillary load and higher risk for immune reactions and pigmentation, especially with clofazimine or minocycline, we prescribed clarithromycin, rifampin, and dapsone for this patient.