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Related to clonal expansion: Clonal selection


1. A group of cells or organisms that are descended from and genetically identical to a single progenitor, such as a bacterial colony whose members arose from a single original cell.
2. An organism developed asexually from another and genetically identical to it, such as an animal produced from an egg cell into which the nucleus of an adult individual has been transferred.
3. A DNA sequence, such as a gene, that is transferred from one organism to another and replicated by genetic engineering techniques.
4. One that copies or closely resembles another, as in appearance or function: "filled with business-school clones in gray and blue suits" (Michael M. Thomas).
v. cloned, clon·ing, clones
1. To make multiple identical copies of (a DNA sequence).
2. To create or propagate (an organism) from a clone cell: clone a sheep.
3. To reproduce or propagate asexually: clone a plant variety.
4. To produce a copy of; imitate closely: "The look has been cloned into cliché" (Cathleen McGuigan).
To grow as a clone.

[Greek klōn, twig.]

clon′al (klō′nəl) adj.
clon′al·ly adv.
clon′er n.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.clonal - of or relating to a clone


[ˈkləʊnəl] ADJclónico
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References in periodicals archive ?
A recent report supported the hypothesis that antimicrobial selection pressure results in clonal expansion of existing resistant strains (10).
Both tumors have the same clonal origin and would thus share at least some degree of genetic similarity, which occurred before the initial clonal expansion.
After the differentiation of 3T3-L1 preadipocytes was induced with a medium containing insulin, the cells undergo several rounds of mitosis referred to as mitotic clonal expansion at an early event of differentiation [15,16], A transcription factor, CCAAT/enhancer binding protein (C/EBP)-[beta], is required for the mitotic clonal expansion [15], After mitotic clonal expansion, the preadipocyte cells express the key transcription factor, PPAR[gamma], for adipocyte differentiation, which plays essential roles for inducing the adipocyte specific PPAR-[gamma] target genes such as Glut-4 and fatty acid binding protein [10], The 3T3-L1 cells gradually increase lipid droplet size and number during the differentiation process.
This method relies on the conservative assumption that any two reads derived from the same biological sample and possessing an identical mutation within one tissue are likely to be the product of clonal expansion rather than independent events.
While such re-assortment is essentially random in nature and thus constantly samples a wide range of "sequence space" or potential binding surfaces, those individual B and T cells whose recombinant markers find a "non-self" match are positively selected for and undergo clonal expansion as the basis for cell-mediated immunity.
Recent studies have subverted the classical view that atherosclerotic plaque macrophages mainly originate from recruited circulating monocytes, launching the new notion that macrophages could also be derived from clonal expansion of resident macrophages or even trans-differentiated vascular smooth muscle cells.
Fast clonal expansion and limited neural stem cell self-renewal in die adult subependymal zone"; Nature Neuroscience, 2015; DOI: 10.
The potential benefit of the HLC quantification method is to provide an accurate quantification for IgA clonal expansion by measuring total IgA[kappa], total IgA[lambda], and IgA[kappa]/IgA[lambda] ratios (9).
Clonal expansion of the myeloid blasts and the loss of normal hematopoiesis are the main characteristic of acute myeloid leukemia.
The discovery that HIV can cause clonal expansion could also have implications for gene therapy, says Angela Ciuffi, a virologist at the University of Lausanne in Switzerland.
Coagulin-L inhibited mitotic clonal expansion (MCE) by delayed entry in G1 to S phase transition and S-phase arrest.
annulata to infect predominantly macrophages/monocytes and B-cells and to transform infected host cells, inducing uncontrolled proliferation and clonal expansion of the parasitized cell population results into the lymphoproliferative disease of cattle (Woods et al.