(redirected from clonal expansion)
Also found in: Thesaurus, Medical, Legal, Financial, Encyclopedia.
Related to clonal expansion: Clonal selection


1. A group of cells or organisms that are descended from and genetically identical to a single progenitor, such as a bacterial colony whose members arose from a single original cell.
2. An organism developed asexually from another and genetically identical to it, such as an animal produced from an egg cell into which the nucleus of an adult individual has been transferred.
3. A DNA sequence, such as a gene, that is transferred from one organism to another and replicated by genetic engineering techniques.
4. One that copies or closely resembles another, as in appearance or function: "filled with business-school clones in gray and blue suits" (Michael M. Thomas).
v. cloned, clon·ing, clones
1. To make multiple identical copies of (a DNA sequence).
2. To create or propagate (an organism) from a clone cell: clone a sheep.
3. To reproduce or propagate asexually: clone a plant variety.
4. To produce a copy of; imitate closely: "The look has been cloned into cliché" (Cathleen McGuigan).
To grow as a clone.

[Greek klōn, twig.]

clon′al (klō′nəl) adj.
clon′al·ly adv.
clon′er n.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.clonal - of or relating to a clone


[ˈkləʊnəl] ADJclónico
Mentioned in ?
References in periodicals archive ?
Recent studies have subverted the classical view that atherosclerotic plaque macrophages mainly originate from recruited circulating monocytes, launching the new notion that macrophages could also be derived from clonal expansion of resident macrophages or even trans-differentiated vascular smooth muscle cells.
Antibiotic resistance genes can also spread through clonal expansion in successful pathogenic strains, for example, KPC in K.
The discovery that HIV can cause clonal expansion could also have implications for gene therapy, says Angela Ciuffi, a virologist at the University of Lausanne in Switzerland.
In a study run by the breast cancer team at Memorial Sloan Kettering Cancer Center (MSKCC), tumor infiltrating lymphocytes (TILs) were evaluated for clonal expansion in breast cancer patients receiving cryoablation and/or ipilimumab.
Coagulin-L inhibited mitotic clonal expansion (MCE) by delayed entry in G1 to S phase transition and S-phase arrest.
In general, lymphocytosis can be classified as belonging to one of two groups: either a reactive polyclonal proliferation, which can be caused by a variety of infective agents, hypersensitivity reactions, autoimmune conditions and splenectomy, or a clonal expansion as a result of a lymphoproliferative disorder.
Moreover, the data indicate that tumors grow by punctuated clonal expansion.
The clonal selection algorithm (CSA) is a special kind of immune algorithms using the clonal expansion and the affinity maturation as the main forces of the evolutionary process.
Maharaj says the clean stem cells allow the immune system to undergo what he calls a clonal expansion.
Although implementation of BBDR models for low-dose risk estimation have been limited mainly to cancer modeled using a two-stage clonal expansion framework, these problems are expected to be present in all attempts at BBDR modeling.
This suggests that MCPyV is involved in clonal expansion of the tumor.