A recent report supported the hypothesis that antimicrobial selection pressure results in clonal expansion
of existing resistant strains (10).
Both tumors have the same clonal origin and would thus share at least some degree of genetic similarity, which occurred before the initial clonal expansion
After the differentiation of 3T3-L1 preadipocytes was induced with a medium containing insulin, the cells undergo several rounds of mitosis referred to as mitotic clonal expansion
at an early event of differentiation [15,16], A transcription factor, CCAAT/enhancer binding protein (C/EBP)-[beta], is required for the mitotic clonal expansion
, After mitotic clonal expansion
, the preadipocyte cells express the key transcription factor, PPAR[gamma], for adipocyte differentiation, which plays essential roles for inducing the adipocyte specific PPAR-[gamma] target genes such as Glut-4 and fatty acid binding protein , The 3T3-L1 cells gradually increase lipid droplet size and number during the differentiation process.
This method relies on the conservative assumption that any two reads derived from the same biological sample and possessing an identical mutation within one tissue are likely to be the product of clonal expansion
rather than independent events.
While such re-assortment is essentially random in nature and thus constantly samples a wide range of "sequence space" or potential binding surfaces, those individual B and T cells whose recombinant markers find a "non-self" match are positively selected for and undergo clonal expansion
as the basis for cell-mediated immunity.
Recent studies have subverted the classical view that atherosclerotic plaque macrophages mainly originate from recruited circulating monocytes, launching the new notion that macrophages could also be derived from clonal expansion
of resident macrophages or even trans-differentiated vascular smooth muscle cells.
Fast clonal expansion
and limited neural stem cell self-renewal in die adult subependymal zone"; Nature Neuroscience, 2015; DOI: 10.
The potential benefit of the HLC quantification method is to provide an accurate quantification for IgA clonal expansion
by measuring total IgA[kappa], total IgA[lambda], and IgA[kappa]/IgA[lambda] ratios (9).
of the myeloid blasts and the loss of normal hematopoiesis are the main characteristic of acute myeloid leukemia.
The discovery that HIV can cause clonal expansion
could also have implications for gene therapy, says Angela Ciuffi, a virologist at the University of Lausanne in Switzerland.
Coagulin-L inhibited mitotic clonal expansion
(MCE) by delayed entry in G1 to S phase transition and S-phase arrest.
annulata to infect predominantly macrophages/monocytes and B-cells and to transform infected host cells, inducing uncontrolled proliferation and clonal expansion
of the parasitized cell population results into the lymphoproliferative disease of cattle (Woods et al.