Both actual cobalamin
levels and levels of methylmalonic acid (MMA) were evaluated in the study cats.
Multiple linear regression was used to investigate the association of cobalamin
with fasting blood sugar level after adjusting for gestational age and gravidity.
Neuropsychiatry disorders caused by cobalamin
deficiency in the absence of anemia or macrocytosis.
Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin
deficiency in Asian Indians.
Performance of the serum cobalamin
assay for diagnosis of cobalamin
Results showed all markers of vitamin B12 status with the exception of plasma cobalamin
were significantly associated with the total ASQ-3 scores in the multiple regression models.
C disease could be divided into early- and late-onset types.
2) In children, for example, mutations in the gene encoding the methylmalonic aciduria and homocystinuria type C (MMACHC) have been identified that result in abnormal cobalamin
C metabolism, termed cobalamin
C disease, which in turn has been associated with endothelial dysfunction, platelet activation, coagulation cascade activation, and increased expression of tissue factor.
Plasma amino acids were also within reference intervals, excluding a combined disorder of cobalamin
and homocysteine metabolism, such as cblC, cblD, or cblF types.
Abbreviations A[beta]: Amyloid-[beta] AdoCbl: Adenosylcobalamin BSO: Buthionine sulfoximine Cbl: Cobalamin
CNCbl: Cyanocobalamin EAAT3: Excitatory amino acid transporter 3 EGF: Epidermal growth factor GSCbl: Glutathionylcobalamin GSH: The reduced glutathione GSSG: The oxidized glutathione HCY: Homocysteine IGF-1: Insulin-like growth factor 1 MeCbl: Methylcobalamin MS: Methionine synthase NAC: N-Acetylcysteine NRG-1: Neuregulin 1 OHCbl: Hydroxocobalamin PI3K: Phosphatidylinositol 3-kinase PLM: Phospholipid methylation PV+: Parvalbumin-expressing SAM: S-Adenosylmethionine SAH: S-Adenosylhomocysteine S[O.
It was reported that cobalamin
had potent superoxide scavenging ability.
The data collected was analysed and a multivariate analysis was done to determine correlation between symptoms, signs and hematological investigations including Bone Marrow aspiration, serum folate and cobalamin
assays and Upper GI Endoscopy.