Interference by arsenite of the activation of p53 via poly-ADP-ribosylation may be involved in its comutagenic and cocarcinogenic
effects (Yu et al.
In relation to the possible cocarcinogenic
association between SV40 and asbestos, it is noteworthy that the peak exposure of the population in the Western world to asbestos appeared to have sharply coincided with the peak exposure to SV40 as a contaminant of polio vaccines.
Hecker E (1968) Cocarcinogenic
principles from the seed oil of Croton tiglium and from other Euphorbiaceae.
Active HSV-1 immunization prevents the cocarcinogenic
activity of HSV-1 in the oral cavity of hamsters.
In addition, there is some evidence that alcohol, even at low doses, increases serum estrogens under certain conditions and that this effect may be another important mechanism involved in alcohol's cocarcinogenic
These results support the theory that As can act through a cocarcinogenic
mechanism of action, exacerbating the genotoxicity and mutagenicity of other compounds.
1999) found no evidence for a cocarcinogenic
or tumor-promoting effect of MF exposure, but the study used different substrains of SD rats than used in the original study.
Over the past few decades, however, several animal studies have indicated that alcohol can have a cocarcinogenic
, or cancer-promoting, effect.