Bioverativ announced that the first patient has been dosed in the Phase 3 clinical program of its investigational therapy BIVV009 for cold agglutinin
disease, or CAgD.
Beyond its two marketed products, Bioverativ's pipeline includes a program in Phase 3 testing for cold agglutinin
disease, and early stage research programs and collaborations in hemophilia, and other rare blood disorders, including sickle cell disease and beta thalassemia.
Herein, we report a case of cold agglutinin
disease (CAD) caused by recurrent viral infections after splenectomy to treat childhood immune thrombocytopenic purpura (ITP).
7) in which 89 adult patients who were diagnosed as having cold agglutinin
disease were evaluated retrospectively, it was reported that more than 90% of the patients had a positive Coombs test with anti-C3.
As part of the acquisition, Bioverativ will obtain worldwide rights to True North's lead candidate, TNT009, a monoclonal antibody in development to treat cold agglutinin
disease, a hemolytic condition.
The category of cold hemolysins includes 2 distinct disease entities: cold agglutinin
syndrome and paroxysmal cold hemoglobinuria, either of which should demonstrate a DAT positive only with C3 antisera.
Food and Drug Administration (FDA) has granted Orphan Drug Designation for the True North Therapeutics's lead product candidate, TNT009 for the treatment of autoimmune hemolytic anemia, including Cold Agglutinin
Disease (CAD), a form of autoimmune hemolytic anemia for which there are limited treatment options available for patients.
The publication is titled ''TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinin
disease patient autoantibodies''.
Q When preheating a specimen with a severe cold agglutinin
does not work (i.
h) Cold Agglutinin
Disease (CAD) is an autoimmune disease characterised by the presence of high concentrations of circulating antibodies, usually IgM, dirested against red blood cells.
Diagnosis and treatment of cold agglutinin
mediated autoimmune hemolytic anemia.
Thrombocytopenia and even pancytopenia may be present, as well as a cold agglutinin
disease characterized by an autoimmune hemolytic anemia.