collagenase


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col·lag·e·nase

 (kə-lăj′ə-nās′, -nāz′, kŏl′ə-jə-)
n.
Any of various enzymes that catalyze the hydrolysis of collagen and gelatin.

collagenase

(ˈkɒlədʒəˌneɪz)
n
(Biochemistry) an enzyme that decomposes collagen
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.collagenase - any enzyme that catalyzes the hydrolysis of collagen and gelatin
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
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References in periodicals archive ?
The EU approval of collagenase clostridium histolyticum is based on results from two pivotal studies, Collagenase Option for Reduction of Dupuytren's (CORD I and CORD II).
A variety of other medications have been used for intralesional injection, including verapamil, nicardipine, interferon alpha-2b, and more recently, collagenase clostridium histolyticum (CCH) (Jordan et al.
They decrease collagenase and elastase levels, and reduce fine lines, roughness and dyspigmentation.
Regulated Expression of Collagenases MMP-1,-8, and-13 aStromelysins MMP-3,-10, and -11 by Human Corneal Epithelial Cells.
Bacterial collagenase activity contributes to biologic mesh resorption such that the biologic material is rapidly degraded without cellular ingrowth leading to high recurrence rates.
It is broken down in the tissues by the catabolic processes, including degradation by specific collagenase enzyme and phagocytosis.
The product, collagenase Clostridium histolyticum, was approved specifically for adults with Dupuytren's contracture with a palpable cord, and will be marketed as Xiaflex by Auxilium Pharmaceuticals Inc.
The Food and Drug Administration's Arthritis Advisory Committee voted 12-0 that the treatment, collagenase clostridium histolyticum, should be approved for treating advanced Dupuytren's, based on the available safety and efficacy data.
Therefore, we studied the involvement of iron and ROS in the modulation of Jun N-terminal kinase 2 (JNK2) activity, c-jun and c-fos mRNA levels, key signaling steps in the transcriptional control of matrix-degrading metalloprotease (MMP)-1/interstitial collagenase and MMP-3/stromelysin-1 after UVB irradiation of human dermal fibroblasts in vitro.
UV irradiation triggered initial events and in subsequent signaling resulting in enhanced expression of two major members of the matrix metalloproteinase family, the interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3), in human dermal fibroblasts (Brenneisen et al.
4, containing 4% bovine serum albumin, 5 mM glucose (KRBH-albumin), 100 mM phenylisopropyl adenosine (PIA), and 1 mg/ml collagenase (type I; Worthington Biochemiclas, NJ, USA) at 37[degrees]C with shaking at 60 cycles/min.
But skin cells are known make an enzyme called collagenase that melts collagen.