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collagenase

   Also found in: Medical, Acronyms, Encyclopedia, Wikipedia 0.01 sec.
col·lag·e·nase  (k-lj-ns, -nz, kl-j-)
n.
Any of various enzymes that catalyze the hydrolysis of collagen and gelatin.
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.collagenase - any enzyme that catalyzes the hydrolysis of collagen and gelatin
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions


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To dissect the underlying control mechanisms for this process, we established a keratinocyte/fibroblast co-culture system and subsequently demonstrated more than a 10-fold increase in collagenase expression in fibroblasts co-cultured with keratinocytes relative to that of control cells.
Therefore, we studied the involvement of iron and ROS in the modulation of Jun N-terminal kinase 2 (JNK2) activity, c-jun and c-fos mRNA levels, key signaling steps in the transcriptional control of matrix-degrading metalloprotease (MMP)-1/interstitial collagenase and MMP-3/stromelysin-1 after UVB irradiation of human dermal fibroblasts in vitro.
Matrix metalloproteinase-1 (MMP-1) is a collagenase (it is also called 'interstitial collagenase') that acts on native (i.
 
 
 
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