The EU approval of collagenase
clostridium histolyticum is based on results from two pivotal studies, Collagenase
Option for Reduction of Dupuytren's (CORD I and CORD II).
A variety of other medications have been used for intralesional injection, including verapamil, nicardipine, interferon alpha-2b, and more recently, collagenase
clostridium histolyticum (CCH) (Jordan et al.
They decrease collagenase
and elastase levels, and reduce fine lines, roughness and dyspigmentation.
Regulated Expression of Collagenases
MMP-1,-8, and-13 aStromelysins MMP-3,-10, and -11 by Human Corneal Epithelial Cells.
activity contributes to biologic mesh resorption such that the biologic material is rapidly degraded without cellular ingrowth leading to high recurrence rates.
It is broken down in the tissues by the catabolic processes, including degradation by specific collagenase
enzyme and phagocytosis.
The product, collagenase
Clostridium histolyticum, was approved specifically for adults with Dupuytren's contracture with a palpable cord, and will be marketed as Xiaflex by Auxilium Pharmaceuticals Inc.
The Food and Drug Administration's Arthritis Advisory Committee voted 12-0 that the treatment, collagenase
clostridium histolyticum, should be approved for treating advanced Dupuytren's, based on the available safety and efficacy data.
Therefore, we studied the involvement of iron and ROS in the modulation of Jun N-terminal kinase 2 (JNK2) activity, c-jun and c-fos mRNA levels, key signaling steps in the transcriptional control of matrix-degrading metalloprotease (MMP)-1/interstitial collagenase
and MMP-3/stromelysin-1 after UVB irradiation of human dermal fibroblasts in vitro.
UV irradiation triggered initial events and in subsequent signaling resulting in enhanced expression of two major members of the matrix metalloproteinase family, the interstitial collagenase
(MMP-1) and stromelysin-1 (MMP-3), in human dermal fibroblasts (Brenneisen et al.
4, containing 4% bovine serum albumin, 5 mM glucose (KRBH-albumin), 100 mM phenylisopropyl adenosine (PIA), and 1 mg/ml collagenase
(type I; Worthington Biochemiclas, NJ, USA) at 37[degrees]C with shaking at 60 cycles/min.
But skin cells are known make an enzyme called collagenase
that melts collagen.