colony-stimulating factor


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colony-stimulating factor

n. Abbr. CSF
1. Any of several cytokines that are produced by a variety of cell types and that stimulate progenitor cells in the bone marrow to produce specific types of blood cells, especially white blood cells such as granulocytes. In vitro, these cytokines stimulate the formation of colonies of cells from a single cell.
2. Any of various recombinant forms of one of these cytokines, such as filgrastim, used as a drug.

colony-stimulating factor

n
(Biochemistry) immunol any of a number of substances, secreted by the bone marrow, that cause stem cells to proliferate and differentiate, forming colonies of specific blood cells. Synthetic forms are being tested for their ability to reduce the toxic effects of chemotherapy. Abbreviation: CSF
References in periodicals archive ?
Growth factors, including granulocyte colony-stimulating factor and erythropoietin, and transfusion support were available to all participants.
F-627 is a recombinant human granulocyte colony-stimulating factor (rhG-CSF) dimer with a best-in-class potential to manage CIN in cancer patients.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) secretion by adherent monocytes measured by quantitative immunoassays.
In the trial, ProscaVax, OncBioMunes novel immunotherapeutic cancer vaccine consisting of a combination of tumor-associated prostate specific antigen (PSA) with the biological adjuvants interleukin-2 (IL-2) and granulocyte-macrophage colony-stimulating factor (GM-CSF), will be evaluated for safety, tolerability and efficacy in treatment-nave prostate cancer patients at disease presentation.
Granulocyte colony-stimulating factor (G-CSF) exerts anti-inflammatory and antiapoptosis effects and stimulates the proliferation of neural stem and progenitor cells in the brain.
Granulocyte colony-stimulating factor (G-CSF) is a member of the cytokine family of growth factors.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is part of the family of hematopoietic cytokines.
Treatment with the oncolytic immunotherapy talimogene laherparepvec (T-VEC) resulted in significantly longer rates of durable response and overall response, compared with subcutaneous granulocyte-macrophage colony-stimulating factor (GM-CSF), according to results from the phase III OPTiM trial reported in the Journal of Clinical Oncology.
A study reported in The American Journal of Gastroenterology found a benefit for the administration of granulocyte colony-stimulating factor (GCSF) in patients with severe alcoholic hepatitis, a condition with high short-term mortality.
In recent years, granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood stem-cells (G-PBSC) have become an alternative stem-cell source.
If given after a heart attack, granulocyte colony-stimulating factor (G-CSF) mobilizes bone marrow stem cells that turn down the collateral damage of cell death that occurs after acute myocardial infarction.
The ODD was granted for use of BL-8040, in combination with granulocyte colony-stimulating factor (G-CSF), to mobilize human stem cells from die bone marrow to the peripheral blood for collection for autologous or allogeneic (donor-based) transplantation.

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