complement fixation

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complement fixation

The binding of active serum complement to an antigen-antibody pair. It is the basis for various diagnostic tests to detect the presence of a specific antigen or antibody.

com′plement fixa`tion

the binding of complement to immune complexes or to certain foreign surfaces, as those of invading microorganisms.
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Noun1.complement fixation - an immune response in which an antigen-antibody combination inactivates a complement (so it is unavailable to participate in a second antigen-antibody combination)
immune reaction, immune response, immunologic response - a bodily defense reaction that recognizes an invading substance (an antigen: such as a virus or fungus or bacteria or transplanted organ) and produces antibodies specific against that antigen
References in periodicals archive ?
A complement fixation reaction test showed a 16-fold increase in this patient's mumps antibody titers.
Serological response of patients suffering from primary and recrudescent typhus: comparison of complement fixation reaction, Weil-Felix test, microimmunofluorescence, and immunoblotting.

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