constant region

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constant region

The portion of the carboxyl terminal of an immunoglobulin's heavy and light chains having an amino acid sequence that does not vary within a given class or subclass of immunoglobulin.

constant region

The portion of the amino acid sequence of an antibody's heavy or light chains that determines the class of the antibody and does not vary within a given class. The constant region terminates in a free carboxyl group (COOH). Unlike the variable region, the constant region does not interact with antigens. Compare variable region.

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allotype heavy chain isotype light chain variable region			L chains of a single chain monoclonal antibody to CD19, Fc represents at least part of a constant region of an IgG. City of Hope obtains United States patent by BIOTECH Patent News Each heavy chain has four constant region domains (C[euro]1-C[euro]4). Molecular mechanisms of allergic disease by deShazo, Richard D. / Southern Medical Journal Using Xencor's PDA[R] technology, researchers engineered the constant region (Fc) of the antibody to increase its affinity for binding FcgRIIb by about 200-fold. Xencor Presents Findings on New Aspect of its Fc Technology Targeting ... by Business Wire			Conspissation Conspurcate Conspurcation const. Constable Constablery Constableship Constabless Constablewick constabular constabulary Constabulatory Constan-=tcedil.gif=-a Constance constancy constant Constant de Rebecque constant dollars Constant Lambert constant load constant of gravitation Constant of integration constant of proportionality constant of the cone constant quantity constant region* constant velocity joint constant-width font Constanta constantan Constantia Constantin Brancusi Constantina Constantine Constantine I Constantine II Constantine the Great Constantine VII Constantine XI Constantinople constantly Constat constatation Constate constative constellate constellation consternate consternation constipate constipated			Constant Power-Control Policy Constant Prepayment on the Balloon Constant Prepayment Rate constant pressure generator Constant Pressure Modulating Outlet Constant Pressure Power Uprate Constant Pressure System constant prices constant progression Constant propagation Constant Propagation Delay Attenuator Constant Proportion Debt Obligation Constant proportion portfolio insurance Constant proportion portfolio insurance Constant Proportion Portfolio Technique Constant Q transform Constant Quality Improvement constant quantity Constant Radial Expansion constant radio code Constant Rate Infusion Constant Rate of Strain constant ratio code Constant ratio plan Constant Ratio Plans constant region Constant Relative Risk-Aversion Constant Resistance Constant returns to scale Constant Ring No Answer Constant Row Weight Ensemble Constant Running Power Take Off Constant Runout Constant Scalar Curvature Kahler Constant Scan Impedance Constant Scheduling Offset constant series Constant Source Constant Source of Disappointment Constant Source Operator's Terminal Constant Source Receive System Constant Source Receiver Suite Constant Special Item ID List Constant Speed Drive Constant Speed Drive Starter Constant Speed Integrated Drive Generator Constant Speed Motor Constant speed propeller Constant speed propeller Constant Spreading Factor Constant State Of Flux

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