The clinical manifestations of contact hypersensitivity
in the mouth vary from subjective difficulties like burning, pain and dryness of the mucosa (burning mouth syndrome) to objective changes within the form of nonspecific stomatitis and cheilitis with reddish, edematous mucosae, erosions and ulcers (1, 79, 80).
Since ACD is a prototype of the cutaneous immune response, and the murine model of ACD, which is called contact hypersensitivity
(CHS), (5) is easily induced, a number of studies have been performed to determine its mechanisms, especially in the sensitization phase.
2) Oral lichenoid reactions may also result from systemic drug exposure, termed as oral lichenoid drug reaction (OLDR), or local allergic contact hypersensitivity
, termed as oral lichenoid contact reaction (OLCR).
reg] cells to prevent both the induction and elicitation of contact hypersensitivity
The first case of contact hypersensitivity
to parthenium in India was recorded from Pune in 196814Paraphenyldiamine is found in hair dyes, fur dyes, leather processing, rubber vulcanizing, printing, photography work, and X ray fluids.
Additionally, topical application of 1-3 ppm avenanthramides mitigated inflammation in murine models of contact hypersensitivity
and neurogenic inflammation and reduced pruritogen-induced scratching in a murine itch model.
Researchers induced contact hypersensitivity
reaction with oxazolone, a chemical allergen used for immunological experiments and found that bortezomib significantly inhibited the contact hypersensitivity
Five earlier safety studies involving a total of 667 patients showed no phototoxicity, contact hypersensitivity
, irritation, photoallergic response, or sensitization.
For example, astilbin alleviated contact hypersensitivity
by inhibiting Th1 cytokine production and stimulating endogenous interleukin-10, and it upregulated the downstream proteins of interleukin-10, suppressor of cytokine signaling 1 (SOCS1), and SOCS3.
The results showed evidence of contact hypersensitivity
to polyurethane 75D and peroxide-cured silicone rubber, which were present in the patient's ICD.
to corticosteroids in routine patch test patients.
1% undecyl dimethyl oxazoline, are able to delay the development of cutaneous contact hypersensitivity
(CHS), according to Nathalie Piccardi, Laboratories Expanscience.