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corepressor |
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| Corepressor requirement and thyroid hormone receptor function during Xenopus development. Studies have identified about 30 different estrogen-receptor-enhancing, or coactivator, proteins, and a few receptor-suppressing, or corepressor, proteins. NH-3 binds to the ligand-binding domain of the TRs, with selectivity for TR[[beta] over TR[alpha], leading to a conformational change of the receptor with release of TR corepressors. |
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