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The process by which squamous epithelial cells in vertebrate animals develop into tough protective layers or structures such as hair, hooves, and the outer layer of skin; the final stage of keratinization.

[Latin cornū, horn; see ker- in Indo-European roots + -fication.]


the process of producing a horn or horny substance


(ˌkɔr nə fɪˈkeɪ ʃən)

the formation of a horny layer of skin, or horny skin structures, as hair, nails, or scales, from squamous epithelial cells.
[1835–45; corn2 + -i- + -fication]


organic change into a hornlike form.
See also: Bones
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References in periodicals archive ?
In cultures of normal human epidermal keratinocytes, treatment with TCDD increased the expression of many genes involved in cornification and EPB formation (Kennedy et al.
Psoriasis vulgaris, chronic (atopic) eczema, hand and foot eczema, skin cornification disorders (ichthyosis), infectious skin diseases, and itching (pruritus and prurigo) are therefore covered as the main dermatological areas of application for the iodine-sulfur springs.
25 times that of 1713-estradiol by a vaginal cornification assay Uones et al.
Paller AS, Mancini AJ: Hereditary Disorder of Cornification.
72) DHEA "switched on" multiple collagen-producing genes and reduced expression of genes associated with production and cornification (hardening) of the tough keratinocytes that form calluses and rough skin.
Austria) explain the ultrastructure, clinical features, biochemical genetics, and cellular pathogenesis of monogenic inherited disorders of cornification.
In metastatic tumors from squamous carcinoma, cavitation might result from cornification of the squamous epithelium in the center of the lesion with subsequent liquefaction and evacuation into airway.