Discovery of seven novel mammalian and avian coronaviruses
in the genus deltacoronavirus supports bat coronaviruses
as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses
as the gene source of gammacoronavirus and deltacoronavirus.
Evolutionary insights into the ecology of coronaviruses
have a number of possible natural hosts, including mice, rats, chickens, cats, and humans.
Our previous experience using our proprietary NEUGENE antisense technology to develop drugs against West Nile and SARS coronaviruses
provides a solid framework for developing therapeutic agents against a broader range of viruses, including hepatitis C and dengue virus, which are important global health issues," said Denis R.
is one of the viruses that infect the respiratory system, which represents about 15 % of the viruses that cause human flu; however this new species are hard to assess, as there isn't any accurate information about its source of infection and the mode of transmission and preventative vaccinations or antibiotic treatments of the virus are unavailable yet.
The 10 coronaviruses
that infect mammals fall into two clusters, each of which contains one virus that causes colds in people.
, which are the major cause of upper respiratory tract illness and accounts for as much as 33% of all cases of the common cold, are positive stranded RNA viruses containing one of the largest viral RNA genomes known to date.
This primer pair can amplify nucleic acids from many coronaviruses
in the subfamily Coronavirinae (9).
are considered to be one of the common agents of the common cold.
commonly cause minor colds in people, but none has previously been linked to an outbreak as serious as the current one.
The most effective NEUGENE design strategy interfered with an RNA processing site unique to the SARS class of coronaviruses
and resulted in a greater than hundredfold reduction in viral expression.
Bats are natural reservoirs of SARS-like coronaviruses