Cross-sensitization and cross-tolerance
between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia.
This acclimatising response is defined as cross-tolerance
(SABEHAT et al.
In addition, NMDA activity "may mean that it reduces some of the cross-tolerance
that we see with patients being converted from another opioid to methadone," she said.
Chronic alcohol treatment can produce not only tolerance to the effects of alcohol but also cross-tolerance
to the effects of nicotine.
Acclimation to Stresses and Cross-Tolerance
between methadone and other opioids is incomplete, switching patients from other opioids to methadone is complex, so patients with a tolerance for other opioids can experience a methadone overdose.
between methadone and other opioids is incomplete, switching patients from other opioids to methadone is complex.
Another mechanism that may contribute to alcohol-nicotine interactions is cross-tolerance
to the effects of both drugs.