cross-tolerance


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cross-tol·er·ance

(krôs′tŏl′ər-əns, krŏs′-)
n.
Tolerance or resistance to an effect or effects of a compound as a result of tolerance previously developed to a pharmacologically similar compound.

cross′-tol′erance



n.
resistance or low reaction to the effects of a drug, poison, etc., because of tolerance to a pharmacologically similar substance.
[1920–25]
References in periodicals archive ?
Cross-sensitization and cross-tolerance between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia.
In addition, NMDA activity "may mean that it reduces some of the cross-tolerance that we see with patients being converted from another opioid to methadone," she said.
Chronic alcohol treatment can produce not only tolerance to the effects of alcohol but also cross-tolerance to the effects of nicotine.
Acclimation to Stresses and Cross-Tolerance To Stresses
Since cross-tolerance between methadone and other opioids is incomplete, switching patients from other opioids to methadone is complex, so patients with a tolerance for other opioids can experience a methadone overdose.
Because cross-tolerance between methadone and other opioids is incomplete, switching patients from other opioids to methadone is complex.
Another mechanism that may contribute to alcohol-nicotine interactions is cross-tolerance to the effects of both drugs.