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1. A cell that has nuclear DNA from one source and cytoplasmic DNA from another, such as a nonhuman animal cell that has had its nucleus replaced by the nucleus of a human somatic cell.
2. A cell line or organism derived from a cybrid cell.

[Blend of cytoplasmic and hybrid.]


(Genetics) a hybrid cell, being a fusion of a whole cell with a cytoplasm, containing a nuclear genome from one source and a mitochondrial genome from another
[c21: from cy(toplasmic) + (hy)brid]
References in periodicals archive ?
Cybrid Technologies also displayed its spray-on self-healing solution for scratch-damaged solar panels at the show.
Because transmitochondrial cybrid cells are often used to verify the pathogenicity of mitochondrial DNA (mtDNA) mutations, we included both control and complex I-deficient (ND1 mutation) cybrid cells.
This review focuses on the potential role of mitochondrial DNA (mtDNA)-related mitochondrial dysfunction in the late-onset, sporadic neurodegenerative diseases and describes the cybrid technique, a research tool useful for studying mtDNA genotype-phenotype relationships.
Two cybrid cell lines carrying 100% wild-type and 100% A3243G mutant mtDNA (25A and 25D, respectively) were made by fusion of human mtDNA-deficient [rho.
State-of-the-art techniques, such as cybrid analysis of electron transport chain defects in the differentiation of nuclear encoded or mitochondrial encoded defects, are also included in this thin book.
We have been using cybrid studies to evaluate inheritance patterns in RC disorders (10), which requires isolation and evaluation of many clones (>20).
The robotic combat simulation game, which challenges players to conquer Cybrid forces to save the Earth, features an all-new RAZOR aircraft and mighty new HERCs in stunning SVGA combat fields, so now you can fly and fight as well as battle on the ground.
The clonal cybrid cells between the cells lacking mitochondrial DNA and fibroblasts from a patient with the A3243G mutation showed poor respiration, an increased ratio of lactate to pyruvate, and marked defects in the mitochondrial morphology and respiratory chain complex I and IV activities (19).
The origin of the complex I defect in PD has been investigated through cybrid technology (12).
April 19 /PRNewswire/ -- Cybernetics announced the immediate availability of the CYBRID series of storage solutions.
MitoKor is the first company to advance cybrid models for neurodegenerative diseases, such as Alzheimer's and Parkinson's, and metabolic disorders such as type II diabetes.
Along with other proprietary technologies, MitoKor has developed novel cybrid (cytoplasmic hybrid) cell lines to model the mitoDNA defects found in the cells of patients suffering from Alzheimer's, Parkinson's, and diabetes.