cyclase


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Related to cyclase: Guanylate cyclase

cy·clase

 (sī′klās′, -klāz′)
n.
An enzyme that acts as a catalyst in the cyclization of a compound.

cyclase

(ˈsaɪkleɪz)
n
an enzyme that acts as a catalyst in the formation of a cyclic compound
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In chapter four, the global PAH market has been segmented into prostacyclin and prostacyclin analogs, endothelin receptor antagonists (ERAs), phosphodiesterase-5 (PDE-5) inhibitors, and soluble guanylate cyclase (sGC) stimulators, based on the commercially-available drug classes, to treat PAH.
based company MSD (through a subsidiary) in the field of soluble guanylate cyclase (sGC) modulation.
For example, in pulmonary endothelium, cAMP produced by plasma membrane-localized adenylyl cyclase is endothelial barrier protective; whereas, cAMP produced by both endogenous and heterologously-expressed AC is barrier disruptive [6,7].
com)-- AnaSpec is pleased to announce the release of the first commercially available 96-well format, fluorimetric assay for measuring Glutaminyl Cyclase (QC) activity - the SensoLyte[R] Green Glutaminyl Cyclase Activity Assay Kit.
The non-selective nitric oxide synthase inhibitor L-NAME, as well as the soluble guanylate cyclase inhibitor MB, attenuated the relaxation of EOFAZ in endothelium-intact rat thoracic aortic rings.
The symposium, titled "pGlu Abeta as Target for AD-Treatment by Glutaminyl Cyclase Inhibition and Passive Immunization," will take place on March 9, 2013 from 09:15 - 11:15 am in Hall B.
Soluble adenylyl cyclase (sAC) is a novel class of adenylyl cyclase, the enzyme responsible for generation of cyclic adenosine monophosphate.
We further demonstrated that G proteins, adenylate cyclase and protein kinase A were required for the increased neuronal excitability.
The W07-toxin could also cause elevation in the adenylate cyclase dependent-cAMP levels in mice enterocytes.
Recent studies have indicated that organophosphorus pesticides (OPs) may disrupt metabolism by altering the expression or function of adenylyl cyclase (AC; the enzyme that catalyzes the formation of cAMP from ATP) or G-protein-coupled receptors and G-proteins involved in the AC signaling cascade.
Probiodrug AG (Halle Saale, Germany) has patented physiological substrates of mammalian glutaminyl cyclase (QC, EC 2.
Type 5 adenylyl cyclase disruption increases longevity and protects against stress.