Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: when is adenylyl cyclase
G proteins couple a diverse superfamily of cell surface receptor proteins, characterized by seven membrane-spanning regions, to a variety of effector elements, such as adenylyl cyclase
, ion channels, and phospholipases (Spiegel et al.
Previous research had shown that G(i)is one of two G proteins that serve as a link between a cellular enzyme called adenylate cyclase
and hormone receptors found on the cell surface: In a complex regulatory process, G(s) stimulates and G(i) inhibits adenylate cyclase
's response to hormones.
Alzheimer's is a complex disease and a difficult therapeutic target, however I believe that glutaminyl cyclase
inhibitors represent the one of the best chances to impact disease biology and even to halt the progression of the disease.
and Canada) in the field of soluble guanylate cyclase
Roberts, both of the Laboratory of Pathology in NIH's National Cancer Institute (NCI), found in mouse and human cell experiments that amyloid-beta, the main component of the plaques that accumulate on brain cells in Alzheimer's, binds to a cell surface receptor called CD36, which causes decreased activity of the enzyme soluble guanylate cyclase
to reduce NO signaling.
Vasoactive intestinal peptide/pituitary adenylyl cyclase
activating peptide receptor 1 (VPAC1) is a G protein coupled receptor that negatively regulates T cell receptor (TCR) activation through a cAMP/PKA signaling dependent pathway when bound by its ligand, vasoactive intestinal peptide (VIP).
During some stages of development, selected regions of the brain are vulnerable to CPF by interference with the G-protein in the adenylyl cyclase
(AC) cascade by disrupting nuclear transcription DNA binding (Meyer et al.
It may be the first clear example of a membrane-associated receptor that activates guanylate cyclase
directly," he says.
Perinatal exposure to environmental tobacco smoke induces adenylyl cyclase
and alters receptor-mediated signaling in brain and heart of neonatal rats.
Expression of mRNA for VEGF, fibroblast growth factor-2 (FGF-2), soluble guanylate cyclase
(sGC, NO receptor), and the angiopoietins (ANG) 1 and 2 by these luteal pericytes was evaluated using real time RT-PCR.
The answer: The gene called ras modulates the activity of a regulatory enzyme called adenylate cyclase