2005) at a substrate concentration of either 1 [micro]M cyclic AMP or 1 [micro]M cyclic GMP
in presence of 10.
Cardiac tissue cyclic GMP
levels were measured by an enzyme immunoassay test-system (R&D Systems, Inc.
7, 8) Nitric oxide triggers the synthesis of cyclic GMP
which causes calcium uptake leading to muscle cell relaxation, vasodilation and increased blood flow to the penis.
According to the research, this is because sildenafil inhibits the breakdown of cyclic GMP
, which has been well known as a messenger molecule used by the body to control blood pressure and flow, and has now been shown to play an important role determining which type of fat-white or brown-the body stores.
The tissues of the penis produce another enzyme, phospho-diesterase-5 (PDE-5), to break down cyclic GMP
and end an erection after ejaculation.
It is known that nitric oxide (the endothelium derived relaxing factor, EDRF) (20) activates soluble guanylyl cyclase, causing the formation of cyclic GMP
and subsequently vascular relaxation (21).
production can be catalyzed by plasma-membrane-receptor guanylyl cyclases or by soluble, cytosolic guanylyl cyclases (Wong and Garbers, 1992; Schmidt et al.
EFFECTS OF CYCLIC GMP
ON ECDYSONE 20-MONOOXYGENASE ACTIVITY.
Several heat-stable peptides produced by enteropathogenic bacteria are capable of inducing intestinal secretion via the intracellular second messenger, cyclic GMP
(Hughes et al.
In the hamster study, scientists measured the animals' blood concentrations of cyclic GMP
45 minutes before changing the light-dark schedule.
The enzyme breaks down a body chemical known as cyclic GMP
, produced during arousal, which causes changes in the muscle and blood vessels leading to an erection.
Exisulind and other of Cell Pathways compounds, which inhibit a cyclic GMP
phosphodiesterase and cell growth, and induce apoptosis (programmed cell death), but do not inhibit COX pathways, are potentially useful for the treatment of precancerous and cancerous lesions.