cyclin


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cy·clin

 (sī′klĭn)
n.
Any of a class of proteins that fluctuate in concentration at specific points during the cell cycle and that regulate the cycle by binding to a kinase.

cyclin

(ˈsaɪklɪn)
n
a type of protein in cell nuclei whose concentration changes cyclically throughout the cell cycle
References in periodicals archive ?
Downregulation of cyclin D1 has been reported to be associated with G1 phase arrest.
DLBCL NOS, cyclin D2 has been reported to be highly specific for de novo [CD5.
To investigate the relationship of miR-143 and ERK5, MAP3K7 or cyclin D1, cells were co-transfected with miR-143 mimic/inhibitor and small interfering RNA targeting (si)-ERK5, si-MAP3K7 or si-cyclin D1 (100 nm, Qiagen).
Key words: Thyroid cancer, papillary [Supplementary Concept]; Thyroid carcinoma, anaplastic; Cyclin Dl; Cyclin-dependent kinase inhibitor p27; RET protein, human
In all groups, 20 paraffin blocks belonging to the primary tumor in the breast were stained by ICAM-1, VCAM-1, Cyclin D1 and Cathepsin D.
Cyclin-dependent kinases (CDKs) contains kinase domain with little kinase activity but on binding with Cyclin, the Cyclin/CDK become an active complex and cause the hyperphosphorylation of pRB that ultimately involve in regulation of transcription and mRNA processing while Cyclin/CDK complex is itself regulated by cell cycle inhibitors of the INK4 (inhibitors of CDK4) and CIP/KIP (CDK interacting protein/kinase inhibitory protein) families, especially p16Ink4a and p21Cip1 (Dyer and Bremner, 2005; Sage, 2012).
Conclusion: In conclusion, our findings strongly suggest that CA promotes a profound deregulation of cell cycle control and reduces the survival of GBM cells via proteasome-mediated degradation of Cyclin Bl, RB and SOX2.
21) Cyclin D1, the product of CCND1 gene, is an important regulator of G1 to S phase progression in many different cell types.
Cyclin D1 expression in a variety of tumors was studied for genetic valuation and some signals were expounded from these studies to hypothesize that amplification of the 11q13 region is tangled in a variety of human tumors [3] including bladder carcinoma, head and neck squamous cell carcinoma, and carcinomas of the esophagus and breast.
Cells with elevated ROS levels were significantly more common after treatment with Ad-Bach1 than after AdGFP or NS injection (Figures 1(b) and 1(c)), and Ad-Bach1 treatment was associated with significantly greater levels of cleaved caspase 3 (Figure 1(d)), which promotes apoptosis, and with lower levels of cyclin D1 (Figure 1(d)), which is required for progression through the G1 phase of the cell cycle.
CYCLIN CLIN YCLIN Y G: Tour of Andalusia (British Tour of Andalusia (British Eurosport, 3.