Comparison of the cell cycle-regulating elements cyclin
A, B, D, and E, and CDKIs p16 and p21 in the control group showed that cyclin
D was expressed most frequently during the GO/G1 phase; the other cyclins
were present in 33% of the cells, and the cyclin
E level was very low.
Abnormal expression of cyclin
D1 and cyclin
-dependent kinases (CDKs) have been considered to be one of the most important factors in the tumourigenesis of various human malignancies.
It is reported that cyclin
L2 is a novel substrate of DYRK1A.
Derailments of the RB-pathway components, cyclin
D1 and cdk4 in particular, seems to participate in the endometrial cancer development in humans.
The researchers speculated that this effect stemmed from the drug's ability to block cyclin
The P53-dependent transactivation of target genes including cyclin
G, P21/wafl/Cipl/mdm2 underwent reversible inhibition by PFT-[alpha] as judged by Northern Blot analysis .
The researchers said breast cancers made of cells containing both the overactive cyclin
D1-CDK4 switch and a mutated cancer-causing gene known as HER-2 were extremely difficult to treat.
In addition, melanomas that did not reveal mutations in BRAF or ras genes had frequent copy number increases and overexpression of cyclin
D1 or CDK4, genes acting downstream of BRAF and ras.
Thus, up-regulation of cyclin
G2 ceases cell proliferation, allowing conservation of energy (Horne et al.
In addition, mouse studies have already resulted in some discoveries about HIV, including the identification of co-receptors, cyclin
T1 (a necessary co-factor for Tat and TAR during transcriptional elongation), and host factors required for viral assembly and release.
D1 is one of a number of genes involved in the cell cycle - the mechanism through which cells to grow and divide.
Wetmore William Jewell College EXPRESSION OF CYCLIN
Bi IN U373 GLIOBLASTOMA MULTIFORME CELLS.