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 (sī′klō-ŏk′sĭ-jə-nās′, -nāz′)
1. See COX-1.
2. See COX-2.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.cyclooxygenase - either of two related enzymes that control the production of prostaglandins and are blocked by aspirin
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
Cox-1, cyclooxygenase-1 - an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys; "an unfortunate side effect of NSAIDs is that they block Cox-1"
Cox-2, cyclooxygenase-2 - an enzyme that makes prostaglandins that cause inflammation and pain and fever; "the beneficial effects of NSAIDs result from their ability to block Cox-2"
References in periodicals archive ?
Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2).
2002) suggested that NSAIDs are responsible for the inhibition of cyclooxygenase dependent pathways responsible for the transcription of proteins that trigger T cells.
James, Roles of cyclooxygenase (COX)-1 and COX-2 in prostanoid production by human endothelial cells: selective up-regulation of prostacyclin synthesis by COX-2, The Journal of Immunology, 167(5), 2831-2838 (2001).
Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin.
Hugely popular non-steroidal anti-inflammation drugs like aspirin, naproxen (marketed as Aleve) and ibuprofen (Advil, Motrin) all work by inhibiting or killing an enzyme called cyclooxygenase -- a key catalyst in production of hormone-like lipid compounds called prostaglandins that are linked to a variety of ailments, from headaches and arthritis to menstrual cramps and wound sepsis.
Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition.
Regional expression of cyclooxygenase isoforms in the rat kidney in complete unilateral ureteral obstruction.
Cyclooxygenase 2 selective inhibitors in cancer treatment and prevention.
Omega-3 fatty acids inhibit an enzyme called cyclooxygenase and reduce the synthesis of arachidonic acid, both of which are associated with inflammation in the body.
Finally in order to evaluate the role of endothelium, nitric oxide (NO) and cyclooxygenase products in producing this action, scientists formed three sub groups of rings, one of which was endothelium deprived.