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cyclooxygenase

   Also found in: Medical, Acronyms, Encyclopedia, Wikipedia 0.03 sec.
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.cyclooxygenase - either of two related enzymes that control the production of prostaglandins and are blocked by aspirin
Cox
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
Cox-1, cyclooxygenase-1 - an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys; "an unfortunate side effect of NSAIDs is that they block Cox-1"
Cox-2, cyclooxygenase-2 - an enzyme that makes prostaglandins that cause inflammation and pain and fever; "the beneficial effects of NSAIDs result from their ability to block Cox-2"


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For example, opioids, such as morphine, promote analgesia not through an anti-inflammatory action like that of an NSAID that inhibits the cyclooxygenase enzyme but by directly counteracting the sensitization of the primary afferent nociceptors or by blocking nociceptive transmission in the spinal cord.
Interferential therapy produces antinociception during application in ... by Tambeli, Claudia H. / Physical Therapy
The team then tested whether oleocanthal could chemically inhibit two inflammation-inducing enzymes, cyclooxygenase (COX) 1 and COX 2.
Olives alive: extra-virgin oil has anti-inflammatory properties by Brownlee, C. / Science News
ibuprofen found in Advil[R] and Motrin[R], are cyclooxygenase (COX)-1 and COX-2 inhibitors.
NSAIDs have their limits in treating OA pain by Running & FitNews
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