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cytokinesis |
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cytokinesis [ˌsaɪtəʊkɪˈniːsɪs -kaɪ-] n (Life Sciences & Allied Applications / Genetics) division of the cytoplasm of a cell, occurring at the end of mitosis or meiosis
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After 44 hr of incubation, cytochalasin-B (Sigma) was added to the culture medium at a final concentration of 6 [micro]g/mL to arrest cytokinesis. Its cellular mode of action against proliferating cells was consistent with Aurora A and B modulation as it inhibited histone H3 phosphorylation, slowed entry into mitosis, blocked cytokinesis and caused polyploidy. The frequency of micronuclei (MN) in peripheral blood lymphocytes determined with the cytokinesis block assay is among the most popular biomarkers used for this purpose, although large inter- and intralaboratory variability of this end point has been observed in population studies. |
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