When a cytologic specimen
demonstrates prominent longitudinal nuclear grooving, a wide range of pathologic lesions should be considered, such as dermatopathic lymphadenopathy.
In this review article, taking and staining methods of cytologic specimen
for the diagnosis of autoimmune bullous diseases, and the cytologic findings have been reviewed.
The 8th subject was 56 years of age when the cytologic specimen
2) Granulocytic sarcoma occurs in 3-7% cases of AML and it can present before, during or even after the diagnosis of AML (7) Granulocytic sarcoma may present as a serous effusion and can be diagnosed on a cytologic specimen
3] The cytologic specimen
in solution is then sent to the laboratory where most of the debris, leukocytes, and erythrocytes are filtered from the specimen and a thin layer Pap test is prepared using a special processor.
In parallel with the need for predictive molecular testing, significant advances in bronchoscopy techniques have enhanced the role of cytology in diagnosis of thoracic malignancies; and the cytologic specimen
is the only available tumor material for diagnosis and molecular marker analyses in up to 44% of lung cancers.
The purposes of this study were (1) to determine the efficacy of a second-generation assay by hybrid capture (HC II) to detect carcinogenic HPV from residual cervical cells of a liquid-based cervical cytologic specimen
, and (2) to compare the performance of this second-generation test with the first-generation hybrid capture (HCT) HPV test of material from direct cervical sampling to detect CIN in women with atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesion (LSIL) Papanicolaou (Pap) smear reports.
Aspiration cytology samples are often more enriched in tumor than their histologic counterparts, and non-formal infixed cytologic specimen
preparations have been shown to provide better quality nucleic acid for molecular testing.
However, it demands that health-care professionals perform cervical screening in a thoughtful and conscientious way so that the cytologic specimen
contains cells from the cervical areas most often involved in disease states.
To assess the extent to which differences in cytologic specimen
types and processing steps influence IHC test results, laboratories should test a selected set of commonly ordered markers (eg, keratin, CD45, S100, ER) in a set of cytologic specimen
types used for IHC staining.
2,14,16,17) Insights gained from these studies provide opportunities to optimize cytologic specimen
triage for ancillary immunocytochemical and molecular studies.
A new question in this survey asked whether laboratories have separate validation procedures for decalcified and cytologic specimens
, and approximately half of laboratories reported having validation procedures specific for these specimen types.