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cytosine |
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cytosine [ˈsaɪtəsɪn] n
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A substitution of cytosine for guanine, also located in VD 1, resulted in Gln instead of Glu at amino acid position 117, as found in genotype B and strain 6BC (numbering according to the ompA amino acid sequence of the C. Intended as a research tool, the T790M quantitative mutation assay detects the presence of a mutant thymidine base in a background of normal cytosine bases at position 2369 of the EGFR gene. Methylation of cytosines in cytosine--guanine (CpG) dinucleotides represents a critical epigenetic DNA modification affecting gene expression and cellular function (Bird 2002). |
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