Through the grant, the company will to further develop its CPAB platform, which can generate CPABs based therapeutics with the unique ability to act on targets located inside the cytosol
and the nucleus of human cancer cells.
That chemical alarm via the molecule cGAS is an important immune-system sensor for DNA that is in the soupy interior of cells, the cytosol
, where DNA should not exist.
This transporter effectively transports dopamine from the cellular cytosol
into synaptic vesicles (pictured below), which effectively sequesters up the dopamine and prevents it from degradation by MAO enzymes + auto-oxidation.
With the translocation domain, the fragment is then transported to endoplasmic reticulum (ER), from which the catalytic domain is released into cytosol
to ribosylates EF-2, leading to its inactivation.
The ER does not itself degrade proteins, so machinery has evolved that moves misfolded proteins into the cytosol
where they can be degraded by the proteasome.
The optical trigger produces a phase change through vaporization of a perfluorocarbon core, achieving direct delivery to the cancer cell cytosol
DHB-induced apoptosis was found to be mediated through mitochondrial intrinsic pathway, evidenced by the loss of MMP, the release of cytochrome c into cytosol
, and the cleavage of caspase-9, caspase-3 and poly (ADP-ribose) polymerase (PARP).
As shown in Figure 9(d), Nrf2 translocation in the cells treated with SPRC (50 [micro]mol/L) was significantly induced from cytosol
to nucleus in a time-dependent manner.
Booth and colleagues say that one cause is the partial blocking of translocator protein sites--sites where ADP is moved into mitochondria for recycling and ATP is moved out of the mitochondria to the cytosol
There are numerous hypotheses that attempt to explain the aging process, considering complex physiological alterations in organisms, including: mitochondrial changes, accumulation of aberrant proteins in the cytosol
, chemical damage to macromolecules, and somatic mutations.
cAMP was either assumed to be released and rapidly distributed throughout the cytosol
, or cAMP was assumed to be released into a near-membrane compartment in which it rapidly equilibrated and subsequent flux into the cytosol
This event triggers the release of pro-apoptotic proteins, including cytochrome C, from the mitochondrial intermembrane space to the cytosol
where they activate caspases and endonucleases that initiates apoptosis.