Vicinium, a fusion protein designed to be a next-generation antibody-drug conjugate (ADC), specifically targets the epithelial cell adhesion molecule (EpCAM) antigens on the surface of bladder cancer cells to deliver a potent cytotoxin
to those cells.
The unique design of the selectively cleavable linker connecting the antibody to the duocarmycin drug leads to high stability in circulation, and induces efficient release of the cytotoxin
in the tumor.
Sporadic cases of haemolytic-uraemic syndrome associated with faecal cytotoxin
-producing Escherichia coli in stools.
pylori vacuolating cytotoxin
A (VacA) protein can interact with lymphocytes, resulting in blockage of IL-2-mediated T cell proliferation.
The vacuolating cytotoxin
gene (vacA) encodes for vacuolating cytotoxin
and found in all strains of H.
According to a new research report by RNCOS entitled, "Global Antibody Drug Conjugates Market By Drug (ADCETRIS, Kadcyla), Pipeline Analysis (By Phase, Mode of Action, Linker, Technology, and Indication) Outlook 2022", in order to overcome these issues, the industry is coming up with more precise and optimal positioning of the link between the cytotoxin
and the antibody, resulting in a "homogeneous" product that may assure more efficient delivery of cytotoxin
to the tumor cell, resulting in better efficacy and less toxicity.
pylori is a Gram-negative bacterium, which can be divided into cytotoxin
-associated antigen (CagA) and vacuolating cytotoxin
(VacA) positive strains, as well as CagA and VacA negative strains.
8) described a thermostable cytotoxin
, which is composed of three LPS-binding proteins, serologically related to the cholera enterotoxin.
10: Current ADCs Launched, Withdrawn and in Phase I/II/III Trials by Sponsor, Indication, Antigen, Cytotoxin
Retired British Colonel Hamish de Bretton-Gordon said the terror group could have access to 20 tons of the cytotoxin
- enough to kill tens of thousands.
exert adverse effect on cell membrane leading to lysis of cell.
lytic activity in synergy with various phospholipases of cobra venom was also reported (Chaim-Matyas et al.