dATP


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Related to dATP: Dato, Ribonucleotide reductase

dATP

 (dē′ā′tē′pē′)
n.
One of the two purine nucleotides that are used to synthesize DNA.

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The quantification of deoxyribonucleoside triphosphate (dNTP) pools, which are the products of RR metabolism, revealed that EGCG, EA, and RA significantly depleted dATP pools with EA also causing a decrease of dCTP pools.
However, when dATP is dispensed, it is incorporated, pyrophosphate is released, and light is emitted.
The researchers found that increased production of the enzyme Ribonucleotide Reductase increased the concentration of dATP within heart cells approximately tenfold, and even though this level was still less than one to two percent of the cell's total pool of ATP, the increase led to a sustained improvement in heart muscle function, with the genetically engineered hearts contracting more quickly and with greater force.
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El exceso en la concentracion de dATP inhibe la ribonucleotido reductasa (RR), produce un desequilibrio en los niveles de dNTPs y propicia rupturas en el ADN de las celulas B (28, Fig.
2] (Invitrogen, USA), 200 [micro]M of dNTP (Invitrogen, USA) containing each of dATP, dCTP, dGTP, dTTP the PCR primers, 2.
5 mmol/L each of dATP, dCTP, dGTP, and 5 mmol/L of dUTP; Applied Biosystems, Foster City, CA, USA), 5 [micro]L of Mg[Cl.
4dNTP's in PCR reagent volumes were prepared with a 1 (dATP):10 (dGTP, dCTP and dTTP) ratio because a lower concentration of dATP helps for more efficient incorporation of [sup.
The supernatant was transferred to a fresh tube, the cDNA reamplified using the same primers and similar PCR conditions except radio-labeled dATP was not used and the dNTP concentrations were increased to 250 [micro]M.