The patients were randomized to either dapsone
5% gel (330 patients) or vehicle (166 patients), applied twice daily for 12 weeks.
of Princeton have agreed in principle upon the terms of a licensing arrangement concerning dapsone
These should be used in combination with another agent such as a retinoid, benzoyl peroxide, adapalene, azelaic acid, or dapsone
The patient was treated with rifampicin 450 mg/day, isoniazid 225 mg/day, pyrazinamide 1200 mg/day and streptomycin 75mg/day, in addition to dapsone
100mg/day and clofazimine 50 mg/day along with a monthly supervised dose of dapsone
100 mg, clofazimine 300 mg and rifampicin 150 mg for first 2 months.
For nonresponders, second-line options include thalidomide, dapsone
, or retinoids.
OTCBB: IMMFF) announced today that its clinical contractor, PRA International, has locked the clinical trial database and has entered into the final stage of analysis of the DAD2000 Phase 2 trial of dapsone
in Alzheimer disease.
For patients with mixed comedonal and inflammatory lesions, topical retinoid monotherapy or a combination of topical retinoid and an antimicrobial agent or topical dapsone
and sulphonamides are the first choice in treatment, with other options including intralesional, topical or oral steroids, niacinamide, tetracycline, colchicine, and chloroquine.
This can be done with any of a number of agents, such as retinoids, benzoyl peroxide, dapsone
, azelaic acid, and even intralesional corticosteroid injections, he said.
Alternative therapies include dapsone
, sulfapyridine, methotrexate, clofazimine, minocycline, colchicine, intravenous immunoglobulins and anti-TNF-a agents.
The treatment given was a combination of prednisone and dapsone
, as well as topical steroids and emollients to use on the affected areas.
Newer classes of medications also are diversifying therapeutic options, including topical dapsone
gel in children 12 years and older.