Also found in: Thesaurus, Medical, Encyclopedia.
Related to dedifferentiate: redifferentiation


n. Biology
Reversion of a specialized cell or tissue to an unspecialized form. Dedifferentiation may occur before the regeneration of appendages in plants and certain animals and in the development of some cancers.

de′dif·fer·en′ti·ate′ v.


vb (intr)
to undergo the process of dedifferentiation
ThesaurusAntonymsRelated WordsSynonymsLegend:
Verb1.dedifferentiate - lose specialization in form or function
develop - grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation, or a conducive environment; "A flower developed on the branch"; "The country developed into a mighty superpower"; "The embryo develops into a fetus"; "This situation has developed over a long time"
differentiate - become different during development; "cells differentiate"
References in periodicals archive ?
The carbohydrate theory, proposed by Allan and Lutz, suggests that a diet too high in carbohydrates, leading to high levels of glucose in the blood, can cause cells to dedifferentiate.
Embryonal sarcoma of the liver: Multiple recurrences and histologic dedifferentiate.
Wounding the plant prompts adjacent cells to dedifferentiate, reverting to their stem cell state, in order to heal the wound.
This remarkable feature, called totipotency, allows for a differentiated cell to dedifferentiate and adopt a proliferative growth pattern (callus), or to deviate towards a developmental program different from the original.
Second, mesenchymal disorganization occurs, in which the mesenchymal cells found below the wound epithelium dedifferentiate and migrate toward the amputation plate.