dedifferentiate


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Related to dedifferentiate: redifferentiation

de·dif·fer·en·ti·a·tion

 (dē′dĭf-ə-rĕn′shē-ā′shən)
n. Biology
Reversion of a specialized cell or tissue to an unspecialized form. Dedifferentiation may occur before the regeneration of appendages in plants and certain animals and in the development of some cancers.

de′dif·fer·en′ti·ate′ v.

dedifferentiate

(ˌdiːdɪfəˈrɛnʃɪˌeɪt)
vb (intr)
to undergo the process of dedifferentiation
ThesaurusAntonymsRelated WordsSynonymsLegend:
Verb1.dedifferentiate - lose specialization in form or function
develop - grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation, or a conducive environment; "A flower developed on the branch"; "The country developed into a mighty superpower"; "The embryo develops into a fetus"; "This situation has developed over a long time"
differentiate - become different during development; "cells differentiate"
References in periodicals archive ?
The most likely explanation is that it's the body's physiological response to tissue damage, which causes tissue-specific stem cells responsible for regeneration and repair to dedifferentiate - or revert to an unspecialized state - and go into overdrive.
Early studies in zebrafish led to the idea that dying retinal cells release signals that trigger support cells in the retinal called Muller glia to dedifferentiate -return to a stem-like state - and proliferate.
Fat stem cells, for example, may change or dedifferentiate when growing in a lab dish, sitting on a warehouse shelf or even following injection into the body, Tuan says.
Alternatively, does HBV infect mature hepatocytes causing them to dedifferentiate into a stem cell lineage as proposed by Arzumanyan et al.
The iPS cells are derived from adult cells which are induced to dedifferentiate following the introduction of genes which code for transcription factors involved in early embryonic development (Fig.
38) We hypothesized that chromatin-modifying agents may induce fibroblasts to dedifferentiate and express pluripotency markers.
Embryonal sarcoma of the liver: Multiple recurrences and histologic dedifferentiate.
One is characterized by lesions that initially demonstrate the morphology of a Solid Multiystic Ameloblastoma but dedifferentiate over time.
The predictive utility of tissue-derived cardiomyocyte pools is limited because they do not spontaneously beat, gradually dedifferentiate into fetal-like physiological states, and contain a high percentage of contaminating cell types, such as fibroblasts that can rapidly override the culture.
Wounding the plant prompts adjacent cells to dedifferentiate, reverting to their stem cell state, in order to heal the wound.