dedifferentiate

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Related to dedifferentiates: dedifferentiated liposarcoma

de·dif·fer·en·ti·a·tion

 (dē′dĭf-ə-rĕn′shē-ā′shən)
n. Biology
Reversion of a specialized cell or tissue to an unspecialized form. Dedifferentiation may occur before the regeneration of appendages in plants and certain animals and in the development of some cancers.

de′dif·fer·en′ti·ate′ v.

dedifferentiate

(ˌdiːdɪfəˈrɛnʃɪˌeɪt)
vb (intr)
to undergo the process of dedifferentiation
ThesaurusAntonymsRelated WordsSynonymsLegend:
Verb1.dedifferentiate - lose specialization in form or function
develop - grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation, or a conducive environment; "A flower developed on the branch"; "The country developed into a mighty superpower"; "The embryo develops into a fetus"; "This situation has developed over a long time"
differentiate - become different during development; "cells differentiate"
References in periodicals archive ?
It is postulated that in collapsing glomerulopathy, unlike other podocytopathies, the podocyte dedifferentiates, and this results in a dysregulated phenotype (8).
Occasionally, association of non-clear cell tumors with sarcomatoid carcinoma has led to the presumption that the former dedifferentiates to form the latter Genetic studies designed to trace the origin of SRCC in association with papillary tumors are limited to 3 case reports,[14,16] with 2 reports[14,15] suggesting a clear cell origin and all 3 failing to confirm a papillary derivation.
Though there are little hard data, a generally accepted phenomenon is that, as a tumor dedifferentiates, its ability to concentrate [sup.