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n. Biology
Reversion of a specialized cell or tissue to an unspecialized form. Dedifferentiation may occur before the regeneration of appendages in plants and certain animals and in the development of some cancers.

de′dif·fer·en′ti·ate′ v.


(Biology) the reversion of the cells of differentiated tissue to a less specialized form


(diˌdɪf əˌrɛn ʃiˈeɪ ʃən)

n. Biol.
the loss of specialized form or condition previously acquired during development.
de`dif•fer•en′ti•ate`, v.i. -at•ed, -at•ing.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.dedifferentiation - the loss of specialization in form or function
adaption, adaptation, adjustment - the process of adapting to something (such as environmental conditions)
References in periodicals archive ?
Louise Hecker , the University of Arizona, "Impaired Myofibroblast Dedifferentiation Contributes to Non-Resolving Fibrosis in Aging"
2,6,7) However, more recent data have suggested that TC-RCCs with focal dedifferentiation (TC-D-RCC) may actually represent hereditary leiomyomatosis RCC syndrome--associated RCC (HLRCC), as some TC-D-RCC cases show loss of fumarate hydratase immunoexpression and S-(2-Succino)-Cysteine (2SC) immunopositivity, similar to HLRCC (Table 1).
Wilms' tumor 1 gene expression in hepatocellular carcinoma promotes ceil dedifferentiation and resistance to chemotherapy.
In general, meristematic cells arise from some parenchyma cells in the peripheral layers of the cortex (subepidermis) that undergo dedifferentiation and start to divide periclinally (Fig.
Tumors that contain RAS mutations have been associated with tumor dedifferentiation, distant metastases, and a poorer survival rate.
Epidemiology - incidence, prevalence, mortality and survival -- Resistance to treatment, tumour (tumour) heterogeneity, dedifferentiation, invasiveness and metastasis -- Personalised medicine, targeted therapy, in vivo diagnostics (IVD) and theranostics -- Cost-effectiveness, pricing and reimbursement -- Payers and healthcare policy.
These are primarily cancer cells, as their level of dedifferentiation facilitates their ability to live outside the body.
All of it carries a detectable odor of industrial processes, suggesting the forcible operations of dedifferentiation it had undergone at the hands of the artist, and all of it is improbably covered in what seems to be decades' worth of weirdly motile, webby dust.
Induction of dedifferentiation, genomewide transcriptional programming, and epigenetic reprogramming by extracts of carcinoma and embryonic stem cells.
According to the authors, a mysterious process triggers residual cells to revert to a less developed state upon tissue damage, a process known as dedifferentiation and understanding the mechanisms could support the design of regenerative therapies that direct human cells to behave similarly and perfectly restore lost tissue.
Thymoma and lupus: apropos of a case with recurrences and histological dedifferentiation.
Medici and Olsen have proposed a mechanism of endothelial-mesenchymal transition (EndMT) [38], described as a form of dedifferentiation of endothelial cells to a stem cell phenotype.