de·gran·u·la·tion (d -gr n y -l  shn)n. The process of losing granules. |
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degranulation |
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Selectin "shedding" occurs because infected cells degranulate, including an EDTA-inhibitable sheddase (metalloprotease), [beta]2-integrins, CD66b, and other inflammatory components such as matrix metalloproteases, which includes gelatinase (MMP9) (38,39). Magnesium probably stabilizes eosinophils (which under certain conditions degranulate major basic protein) and mast cells (which degranulate histamine). 2000 Diesel exhaust particles directly induce activated mast cells to degranulate and increase histamine levels and symptom severity J Allergy Clin Immunol 106:1140-1146. |
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