Several mechanisms have been suggested by Transcranial Magnetic Stimulation studies for dystonia, including transversely spreading ephactic activation originating the axon within the partially demyelinated
lesion at any level of motor fiber tracts, and axonal irritability secondary to releasing of inflammatory mediators (4,5).
A month later, the new cells had incorporated into the demyelinated
area where new myelin, the protein insulation that protects nerves, was being produced.
2) JCV remains in a latent state within renal tubular epithelial cells until an immunosuppressive condition arises, and its reactivation results in lysis of oligodendrocytes, development of demyelinated
plaques, and leukoencephalopathic destruction.
This functional improvement correlated with a statistical decrease in demyelinated
lesions in the nervous system of cell treated animals compared to placebo as well as increased remyelination in cell treated animals, and this result has been confirmed in a second animal model of MS, suggesting that MultiStem treatment may accelerate the process of axonal remyelination.
Fampridine "improves conduction in demyelinated
axons," according to the manufacturer, Acorda Therapeutics Inc.
19,20) CD8+ T-cells are concentrated in the recently demyelinated
core of active MS lesions, appear in small clusters, and express granzyme B in their cytotoxic granules, features that suggest an antigen-driven, cytotoxic process (unpublished data).
Exposure to NO "has been shown to cause axonal degeneration or block axonal conduction, especially in axons that are physiologically active or demyelinated
Exposure to nitrous oxide "has been shown to cause axonal degeneration or block axonal conduction, especially in axons that are physiologically active or demyelinated
As an acknowledgment of his painstaking, groundbreaking research on nerve fibers that have lost their protective myelin coat and become, in medical terms, demyelinated
, the American Academy of Neurology and the National Multiple Sclerosis Society awarded Dr.
fibers do not conduct rapid trains of stimuli as well as myelinated fibers and go into conduction block after repeated use.
Research within the PVA/ EPVA Center indicates that some demyelinated
neurons may misexpress sodium channels so that they produce inappropriate mixtures of these molecular batteries and therefore fire in abnormal patterns.
Messages sent through demyelinated
axon segments arrive late producing an uncoordinated response within the neural chain which can produce specific symptoms such as paralysis and visual impairment or less specific symptoms such as fatigue (Wolf, 1984).