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denature
(redirected from denaturation)

   Also found in: Medical, Legal, Encyclopedia, Wikipedia, Hutchinson 0.01 sec.
de·na·ture  (d-nchr)
tr.v. de·na·tured, de·na·tur·ing, de·na·tures
1. To change the nature or natural qualities of.
2. To render unfit to eat or drink without destroying usefulness in other applications, especially to add methanol to (ethyl alcohol).
3. Biochemistry
a. To cause the tertiary structure of (a protein) to unfold, as with heat, alkali, or acid, so that some of its original properties, especially its biological activity, are diminished or eliminated.
b. To cause the paired strands of (double-stranded DNA) to separate into individual single strands.
4. Physics To add nonfissionable matter to (fissionable material) so as to prevent use in an atomic weapon.

de·natur·ant n.
de·natur·ation n.

denature [diːˈneɪtʃə], denaturize, denaturise [diːˈneɪtʃəˌraɪz]
vb (tr)
1. to change the nature of
2. (Chemistry) to change (a protein) by chemical or physical means, such as the action of acid or heat, to cause loss of solubility, biological activity, etc.
3. (Chemistry) to render (something, such as ethanol) unfit for consumption by adding nauseous substances
4. (Physics / Nuclear Physics) to render (fissile material) unfit for use in nuclear weapons by addition of an isotope
denaturant  n
denaturation  n

denature  (d-nchr)
1. To cause the tertiary structure of a protein to unfold, as with heat, alkali, or acid, so that some of its original properties, especially its biological activity, are diminished or eliminated.
2. To cause the paired strands of DNA to separate into individual strands.
ThesaurusLegend:  Synonyms Related Words Antonyms
Verb1.denature - add nonfissionable material to (fissionable material) so as to make unsuitable for use in an atomic bomb
alter, change, modify - cause to change; make different; cause a transformation; "The advent of the automobile may have altered the growth pattern of the city"; "The discussion has changed my thinking about the issue"
2.denature - modify (as a native protein) especially by heat, acid, alkali, or ultraviolet radiation so that all of the original properties are removed or diminished
alter, change, modify - cause to change; make different; cause a transformation; "The advent of the automobile may have altered the growth pattern of the city"; "The discussion has changed my thinking about the issue"
3.denature - make (alcohol) unfit for drinking without impairing usefulness for other purposes
alter, change, modify - cause to change; make different; cause a transformation; "The advent of the automobile may have altered the growth pattern of the city"; "The discussion has changed my thinking about the issue"
Translations
denature
vtdenaturieren; (= make unfit for eating, drinking also)ungenießbar machen


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? Mentioned in ? References in periodicals archive
 
Each PCR cycle consisted of annealing at 68[degrees]C for 1 min, primer extension at 72[degrees]C for 5 min, and denaturation at 94[degrees]C for 1 min.
The micronization process prevents the beans from losing their flavor as a result of heat denaturation.
30 sec of template denaturation at 92[degrees]C if using 3'MGB quencher, or at 95[degrees]C if using 3'TAMRA quencher (step 3), and 1 min of assay-specific annealing at 60[degrees]C (step 4).
 
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