Horst Sievert, an interventional cardiologist who collaborated on one of the efficacy trials and now routinely performs renal denervations at the cardiovascular center of Saint Katharinen Hospital in Frankfurt, Germany
pivotal trial assessing renal denervation for blood pressure reduction began in October and a report on its final results won't appear until next year, but excitement based on earlier study findings and the European clinical experience is already running high for this new approach to treating drug-resistant hypertension.
Renal denervation "could arguably be the most exciting advance in interventional vascular medicine," said Dr.
2001; Van Cruchten & Van Den Broeck, 2002), to confirm the occurrence of apoptosis in two muscles (red and white), submitted to experimental denervations.
It was demonstrated that this phenomenon takes place in a more marked way, in the beginning of the denervation process.
In this muscle, as the denervation time elapses owing to the decrease of contractive structures and alterations in the number of membranous organelles, there is a reduction in myosin and actine syntheses, which in turn results in a decrease in the size of fibers and resorption of myofibrils (Tischeler et al.
The effects of sequential exposure, first to a LNa diet for 7 days and then to a HNa diet for 21 days, in rats with and without chronic bilateral aortic denervation (partial barodenervation), on MAP, SSi, and pNOB were tested in S-I, and on baseline and NADH-stimulated renal medullary superoxide anion production (RMSAP) and renal mRNA expression of NAD(P)H oxidase and SOD at the end of a HNa diet in S-II.
When rats reached 200-235 g body weight, MAP was measured when the rats were in a conscious state before aortic denervation [predenervation MAP (pdMAP)].
Then, rats received 90 mg/kg sodium ceftriaxone (Amcef, AMSA, Mexico) ia and were subjected to sham or real aortic denervation.
Moreover, ort top of the expected antihypertensive effect of renal denervation, recent results from a pilot, randomized controlled study of 50 hypertensive patients suggested that the intervention could help normalize glucose metabolism and reverse type 2 diabetes in some patients.
The Symplicity Renal Denervation System, developed by Ardian, now owned by Medtronic, has been available in Europe and Australia since 2010.
The largest systematic assessment of the antihypertensive impact of renal denervation carne in a randomized trial, Symplicity HTN-2, of 106 patients, sponsored by Ardian and published in 2010.