TRE-515 is a novel, first-in-class inhibitor of deoxycytidine
kinase for the treatment of patients with myelodysplastic syndromes (MDS).
Intracellular cytarabine triphosphate production correlates to deoxycytidine
kinase/ cytosolic 5'-nucleotidase II expression ratio in primary acute myeloid leukaemia cells.
The most prevalent nucleotide was deoxycytidine
monophosphate, accounting for nearly 27% of all nucleotides within the studied MC4R gene sequence.
It is a pro-drug analogue of cytidine that when transported into cells, is phosphorylated by deoxycytidine
kinase to its active diphosphate and triphosphate forms--dFdCDP and dFdCTP.
Radu, Nathanson and their colleagues found that an important nucleotide called deoxycytidine
triphosphate (dCTP) is produced by two pathways, the de novo pathway and the nucleoside salvage pathway.
EMT 5'-triphosphate inhibits the activity of the HIV-1 RT by competing with the natural substrate deoxycytidine
5'-triphosphate and by being incorporated into nascent viral DNA which results in chain termination.
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'- deoxycytidine
(decitabine) in hematopoietic malignancies.
Base Nucleoside Nucleotide Adenine deoxyguanosine deoxyguanylate Guanine deoxyguanosine deoxyguanylate Cytosine deoxycytidine
deoxycytidylate Thymine deoxythymdine deoxythymidylate Table 1.
Endogenous oxidative damage of deoxycytidine
ABBREVIATIONS: bDNA = Branched DNA; DNA = Deoxyribonucleic Acid; dNTP = Deoxyribonucleotides; dATP = Deoxyadenosine Triphosphate; dCTP = Deoxycytidine
Triphosphate; dGTP = Deoxyguanosine Triphosphate; dTTP = Deoxythymidine Triphosphate; FDA = Food and Drug Administration; FRET = Fluorescence Resonance Energy Transfer; MRSA = Methicillin Resistant Staph aureus; MTB = Mycobacterium tuberculosis; NASBA = Nucleic Acid Sequence Based Amplification; PCR = Polymerase Chain Reaction; PFGE = Pulsed-Field Gel Electrophoresis; RT-PCR = Reverse Transcription Polymerase Chain Reaction; Taq = Thermus aquaticus; TMA = Transcription-Mediated Amplification; VRE = Vancomycin Resistant Enterococcus.
Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine
kinase toward antiviral and cytostatic nucleoside analogs.
Gemzar[R] requires the enzyme deoxycytidine
kinase (DCK)--manufactured within the cancer cell--to become fully activated.