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Related to deoxycytidine: deoxycytidine monophosphate, deoxythymidine
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Noun1.deoxycytidine - a nucleoside component of DNA; composed of cytosine and deoxyribose
nucleoside - a glycoside formed by partial hydrolysis of a nucleic acid
References in periodicals archive ?
TRE-515 is a novel, first-in-class inhibitor of deoxycytidine kinase for the treatment of patients with myelodysplastic syndromes (MDS).
Intracellular cytarabine triphosphate production correlates to deoxycytidine kinase/ cytosolic 5'-nucleotidase II expression ratio in primary acute myeloid leukaemia cells.
The most prevalent nucleotide was deoxycytidine monophosphate, accounting for nearly 27% of all nucleotides within the studied MC4R gene sequence.
It is a pro-drug analogue of cytidine that when transported into cells, is phosphorylated by deoxycytidine kinase to its active diphosphate and triphosphate forms--dFdCDP and dFdCTP.
Radu, Nathanson and their colleagues found that an important nucleotide called deoxycytidine triphosphate (dCTP) is produced by two pathways, the de novo pathway and the nucleoside salvage pathway.
EMT 5'-triphosphate inhibits the activity of the HIV-1 RT by competing with the natural substrate deoxycytidine 5'-triphosphate and by being incorporated into nascent viral DNA which results in chain termination.
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'- deoxycytidine (decitabine) in hematopoietic malignancies.
Base Nucleoside Nucleotide Adenine deoxyguanosine deoxyguanylate Guanine deoxyguanosine deoxyguanylate Cytosine deoxycytidine deoxycytidylate Thymine deoxythymdine deoxythymidylate Table 1.
ABBREVIATIONS: bDNA = Branched DNA; DNA = Deoxyribonucleic Acid; dNTP = Deoxyribonucleotides; dATP = Deoxyadenosine Triphosphate; dCTP = Deoxycytidine Triphosphate; dGTP = Deoxyguanosine Triphosphate; dTTP = Deoxythymidine Triphosphate; FDA = Food and Drug Administration; FRET = Fluorescence Resonance Energy Transfer; MRSA = Methicillin Resistant Staph aureus; MTB = Mycobacterium tuberculosis; NASBA = Nucleic Acid Sequence Based Amplification; PCR = Polymerase Chain Reaction; PFGE = Pulsed-Field Gel Electrophoresis; RT-PCR = Reverse Transcription Polymerase Chain Reaction; Taq = Thermus aquaticus; TMA = Transcription-Mediated Amplification; VRE = Vancomycin Resistant Enterococcus.
Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogs.
Gemzar[R] requires the enzyme deoxycytidine kinase (DCK)--manufactured within the cancer cell--to become fully activated.