Therefore relating this to the modern day depurative use, the P-glycoprotein can transport the berberine through the cell membranes and through over expression can increase the efficient removal of the toxins from the cell that have caused the skin condition to occur.
Scientific evaluation of the use of traditional depuratives via modulation of ABC transporters.
They take this further in their 2001 work when they add that P-glycoprotein can inhibit apoptosis and provide protection to the cells against toxins that require the use of depuratives for tissue cleansing.
This therefore requires knowledge of which herbs induce and which inhibit P-glycoprotein to gain a deeper understanding of which of our traditional herbs can be confirmed as acting as depuratives in this way and which other herbs can now be reclassified as depuratives in the modern sense.
This created the possibility that if over-expression removed the toxins from the cell, then herbs that increase the P-glycoprotein expression would prove to be the modern day depuratives.
It does however do three things: a) opens up new avenues as to the reclassification of some of our herbs that have not been considered depuratives before this discovery was made; b) redefines old herbs not classically referred to as depuratives, as depuratives using modern cellular detoxification knowledge; and c) offers some explanation as to why skin problems do not respond to some of our traditional depuratives.