desipramine


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de·sip·ra·mine

 (dĭ-zĭp′rə-mēn, dĕz′ə-prăm′ĭn)
n.
A tricyclic antidepressant drug, C18H22N2, used in its hydrochloride form.

[desmethyl (des- variant of de- + methyl) + (im)ipramine.]

desipramine

(dəˈsɪprəˌmiːn)
n
a tricyclic antidepressant drug
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.desipramine - a tricyclic antidepressant drug that activates the psychomotor system
tricyclic, tricyclic antidepressant, tricyclic antidepressant drug - an antidepressant drug that acts by blocking the reuptake of norepinephrine and serotonin and thus making more of those substances available to act on receptors in the brain
Translations

desipramine

n desipramina
References in periodicals archive ?
Another option, which may have more appreciable side effects but no serotonin activity, is desipramine (Benowitz, 2014).
Since Myrbetriq is a moderate CYP2D6 inhibitor, the systemic exposure to CYP2D6 substrates such as metoprolol and desipramine is increased when coadministered with Myrbetriq.
Paraphilias: A double-blind crossover comparison of clomipramine versus desipramine.
Jesus' team, with colleagues in Sao Paulo, Brazil, reviewed the literature for drug treatment of trichotillomania, and found varying evidence for the use of several drugs, including clomipramine, desipramine, fluoxetine, naltrexone, and citalopram.
The existing method was a multianalyte assay that involved the addition of a calibration solution containing deuterated internal standards (ISs) for 4 TCAs (amitriptyline, desipramine, imipramine, and NT) (15), but same chromatographic method was also used for a NT-only assay for the purposes of the current study.
Examples of medicinal products metabolised by CYP2D6 include metoprolol, propranolol, desipramine, venlafaxine, haloperidol, risperidone, propafenone, flecanide, codeine, oxycodone and tramadol (the latter three products requiring CYP2D6 to form their active analgesic metabolites).
Death of two subjects due to imipramine and desipramine metabolite accumulation during chronic therapy: a review of the literature and possible mechanisms.
Imipramine, amitriptyline, and desipramine have mixed norepinephrine and 5-HT enhancement as their mechanism of action.
When first-and second-line interventions fail, consider desipramine or nortriptyline.
The first, by Kruesi and colleagues (1992), compared clomipramine versus desipramine, with a two-week, single-blind placebo lead in.
Type of Pain Class of Medication (with generic examples) Neurogenic pain (nerve pain), Antidepressant agents: Tricyclic chronic or episodic, such as (amitriptyline, nortriptyline, burning, tingling, pins and desipramine.
Desipramine and nortriptyline appear to be better tolerated in the elderly due to fewer anticholinergic effects.