Another option, which may have more appreciable side effects but no serotonin activity, is desipramine
Since Myrbetriq is a moderate CYP2D6 inhibitor, the systemic exposure to CYP2D6 substrates such as metoprolol and desipramine
is increased when coadministered with Myrbetriq.
Paraphilias: A double-blind crossover comparison of clomipramine versus desipramine
Jesus' team, with colleagues in Sao Paulo, Brazil, reviewed the literature for drug treatment of trichotillomania, and found varying evidence for the use of several drugs, including clomipramine, desipramine
, fluoxetine, naltrexone, and citalopram.
The existing method was a multianalyte assay that involved the addition of a calibration solution containing deuterated internal standards (ISs) for 4 TCAs (amitriptyline, desipramine
, imipramine, and NT) (15), but same chromatographic method was also used for a NT-only assay for the purposes of the current study.
Examples of medicinal products metabolised by CYP2D6 include metoprolol, propranolol, desipramine
, venlafaxine, haloperidol, risperidone, propafenone, flecanide, codeine, oxycodone and tramadol (the latter three products requiring CYP2D6 to form their active analgesic metabolites).
Death of two subjects due to imipramine and desipramine
metabolite accumulation during chronic therapy: a review of the literature and possible mechanisms.
Imipramine, amitriptyline, and desipramine
have mixed norepinephrine and 5-HT enhancement as their mechanism of action.
When first-and second-line interventions fail, consider desipramine
The first, by Kruesi and colleagues (1992), compared clomipramine versus desipramine
, with a two-week, single-blind placebo lead in.
Type of Pain Class of Medication (with generic examples) Neurogenic pain (nerve pain), Antidepressant agents: Tricyclic chronic or episodic, such as (amitriptyline, nortriptyline, burning, tingling, pins and desipramine
and nortriptyline appear to be better tolerated in the elderly due to fewer anticholinergic effects.