The National Institute on Drug Abuse (NIDA) also lists Dextromethorphan
as one of the two commonly abused cough and cold medicines, the other being Promethazine-codeine cough syrup.
A placebo-controlled trial demonstrated that co-administering quinidine with dextromethorphan
limits measures of positive reinforcement, such as euphoria and drug liking.
Wang called it unlikely that manufacturers would formulate cold and cough medications without diphenhydramine or dextromethorphan
because these drugs have the antitussive and sedative properties that consumers seek from cough and cold medications.
The formulation of dextromethorphan
and quinidine used in the study already has Food and Drug Administration marketing approval with the brand name Nuedexta for treating pseudobulbar affect (PBA), which can occur in patients with, for example, amyotrophic lateral sclerosis or multiple sclerosis.
The 93 patients randomized to the investigational treatment started on 20 mg dextromethorphan
and 10 mg quinidine administered orally once daily for a week, followed by an up-titration schedule over a period of 2 weeks to reach 30 mg dextromethorphan
twice daily plus 10 mg quinidine twice daily, the dosage they continued for an additional 7 weeks.
Like every medication, dextromethorphan
has side effects," Dr.
Tests show the victims' stomachs contained dextromethorphan
, a synthetic morphine derivative used in cough syrup that can have mind-altering effects if consumed in large quantities.
The substance dextromethorphan
has been identified as an active ingredient in Tyno cough syrup.
The effects of Danshen and its active components (tanshinone I, tanshinone IIA, dihydrotanshinone and cryptotanshinone) on CYP2D6 activity was investigated by measuring the metabolism of a model CYP2D6 probe substrate, dextromethorphan
to dextrorphan in human pooled liver microsomes.
Honey appears to be preferable to dextromethorphan
and diphenhydramine, both because of its greater efficacy and a lower risk of side effects.
Summary: TEHRAN (FNA)- Iranian researchers produced a new nanosensor at laboratory scale for specifying and measuring the amount of Dextromethorphan
in cough suppressant drugs used during cold.
BOIRON IS LAUNCHING CHESTAL, a natural cough syrup that is free of dextromethorphan
, into retail outlets.