and stavudine became available for US$1 per day.
Over an 18-year period, the FDA's Adverse Event Reporting System received 42 reports of noncirrhotic portal hypertension in patients aged 10-66 years taking didanosine
(Videx, Bristol-Myers Squibb) or the delayed-release formulation (VidexEC).
resistance is associated with mutations at positions 65 and 74.
Data are not available to recommend a dose adjustment of didanosine
for patients weighing less than 60 kg.
and lamivudine were administered in an investigational once-daily dosing schedule.
However, the combination of zalcitabine/ zidovudine was no better than didanosine
Zidovudine resistance mutations have been shown to occur in antiretroviral naive patients assigned to stavudine/ didanosine
therapy, although this resistance has not been substantiated phenotypically.
Because of potential problems with drug absorption, amprenavir should be taken at least 1 hour before or after an antacid or didanosine
The risk of neuropathy was additive or even synergistic for didanosine
/stavudine/hydroxyurea compared to didanosine
or stavudine alone.
Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues alone or in combination, including didanosine
and other antiretrovirals.
In particular, the recent use of the nucleos(t)ide reverse transcriptase inhibitors abacavir and didanosine
has been associated with myocardial infarction in the large DAD study cohort .
Regimen 2' includes the combination of didanosine
, zidovudine and lopinavir/ritonavir.