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didanosine |
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6%) initially received only 2 NRTIs (lamivudine and zidovudine for 7 months in 1 case; stavudine and didanosine for 14 months in the other). For those beginning antiretrovirals, the guidelines now say that the combination of an NNRTI + didanosine plus tenofovir should not be used, due to virologic failure and development of resistance. Didanosine labeling states that the dose of ddI should be reduced when co-administered with tenofovir because of increased risks of ddI toxicity, including pancreatitis. |
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