scleroderma

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scle·ro·der·ma

 (sklîr′ə-dûr′mə)
n.
A pathological thickening and hardening of the skin.

scleroderma

(ˌsklɪərəʊˈdɜːmə) ,

sclerodermia

or

scleriasis

n
(Pathology) a chronic progressive disease most common among women, characterized by a local or diffuse thickening and hardening of the skin
[C19: from New Latin sclerōdermus, from Greek, from sklēros hard + derma skin]

scle•ro•der•ma

(ˌsklɪər əˈdɜr mə, ˌsklɛr-)

n.
a disease in which connective tissued becomes hardened and rigid.
[1865–70]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.scleroderma - an autoimmune disease that affects the blood vessels and connective tissuescleroderma - an autoimmune disease that affects the blood vessels and connective tissue; fibrous connective tissue is deposited in the skin
autoimmune disease, autoimmune disorder - any of a large group of diseases characterized by abnormal functioning of the immune system that causes your immune system to produce antibodies against your own tissues
morphea - localized scleroderma
2.Scleroderma - genus of poisonous fungi having hard-skinned fruiting bodies: false truffles
fungus genus - includes lichen genera
family Sclerodermataceae, Sclerodermataceae - a family of fungi or order Sclerodermatales with a single-layered peridium; includes earthballs
earthball, hard-skinned puffball, puffball, false truffle - any of various fungi of the genus Scleroderma having hard-skinned subterranean fruiting bodies resembling truffles
Scleroderma aurantium, Scleroderma citrinum - an earthball fungus that is a dingy brownish yellow and a dark purplish interior; the peridium is covered with a pattern of small warts
Scleroderma flavidium, star earthball - an earthball with a smooth upper surface that is at first buried in sand; the top of the fruiting body opens up to form segments like the ray of an umbel
Scleroderma bovista, smooth earthball - an earthball with a peridium that is firm dry and smooth when young but developing cracks when mature; pale orange-yellow when young and reddish brown at maturity
Translations

scle·ro·der·ma

n. escleroderma, esclerodermia, induración y casi total atrofia de la epidermis.

scleroderma

n esclerodermia, esclerosis sistémica progresiva; localized — esclerodermia localizada
References in periodicals archive ?
Cohen will provide an update on the Company's progress and anticipated near-term clinical development milestones for Resunab(TM), a novel synthetic oral specialized pro-resolving mediator drug with unique anti-inflammatory and anti-fibrotic activity, with initial treatment indications in both diffuse scleroderma and cystic fibrosis.
A randomized, controlled trial of methotrexate versus placebo in early diffuse scleroderma.
For the study, investigators at Hospital for Special Surgery enrolled 30 patients with diffuse scleroderma, a widespread severe form of the disease, and gave them 400 mg of Gleevec per day.
Comparison of CREST syndrome variant with diffuse scleroderma.
Skin thickening scores also improved significantly more in the patients with diffuse scleroderma who received treatment with cyclophosphamide.
Physiologic abnormalities of cardiac function in progressive systemic sclerosis with diffuse scleroderma.
First, the skin involvement in diffuse scleroderma can occur anywhere, whereas in limited scleroderma the telangiectasias involve only the face, feet, forearms, and hands, with skin thickening limited to the face and hands (4, 5).

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