g) lbuprofen, aceclofenac, acemetacin, dexibuprofen, dexketoprofen, diclofenac sodium, diflunisal
, etodolac, fenbufen, fenoprofen, flurbiprofen, ibuprofen, indometacin, ketoprofen, mefenamic acid, meloxicam, nabumetone, naproxen, piroxicam, sulindac, tenoxicam, tiaprofenic acid, diclofenac/misoprostol.
The researchers discovered that salicylic acid, a major compound in aspirin, and diflunisal
, an analgesic that's derived from salicylic acid, suppress two key proteins, p300 and CREB-binding protein.
Stables, Synthesis and Biological Activities of Diflunisal
NSAID classification Non-selective inhibition Acetic acid Proprionic acid Fenamate derivatives derivatives derivatives * Diclofenac * Fenoprofen * Meclofenamate * Etodolac * Flurbiprofen * Mefenamic acid * Indomethacin * Ibuprofen * Sulindac * Ketoprofen * Tolmetin * Naproxen * Oxaprozin Naphthyl alkanone Salicylates * Nabumetone * Aspirin * Diflunisal
* Choline magnesium trisalicylate * Salicylate Enolic acid derivatives * Piroxicam * Meloxicam Selective COX-2 inhibition * Celecoxib * Rofecoxib Table 9.
6) In an RCT (LOE Ib), the analgesic effect of diflunisal
was evaluated and was reported to be superior to a placebo.
Orally administered diflunisal
stabilizes transthyretin against dissociation required from amyloidogenesis.
Treatment of rats with a specific [beta]-glucuronidase inhibitor decreased metabolic clearance of diflunisal
by 54% in experiments in which the bile duct was cannulated to prevent enterohepatic recirculation (Brunelle and Verbeeck 1997).
Sex-difference and the effects of smoking and oral contraceptive steroids on the kinetics of diflunisal
Commonly used drugs in dentistry and their use in patients with acute porphyrias [Taken from: British National Formulary, 2006 and The European Porphyria Initiave, 2007] Considered Considered Drug Category Unsafe Safe Local anaesthetics Lignocaine * Lignocaine *, Prilocaine, Bupivacaine Intravenous Barbiturates Midazolom, Propofol anaesthetics Inhalation Enflurane, Halothane Nitrous Oxide, Anaesthetics Isoflurane Premedication / Diazepam Midazolom, Temazepam sedative Non opiod analgesics Diclofenac, Aspirin, Diflunisal
, Mefanamic acid Dihydrocodeine Ibuprofen, Paracetamol.
The nonacetylated salicylates, including salsalate, magnesium choline trisalicylate, and diflunisal
, as well as several of the nonsalicylate NSAIDs, such as low-dose etodolac, low-dose ibuprofen, and nabumetone, are reportedly less toxic to the GI mucosa than the other NS-NSAIDs.
We added 100 [micro]L diflunisal
phosphate solution (0.
4%) exposed to diflunisal
, 143 birth defects among the 3,178 women (4.