WASHINGTON--Avoid the use of digoxin
in patients with atrial fibrillation, judging from a secondary analysis of the 18,000-patient ARISTOTLE trial.
WASHINGTON -- In what could prove to be the final word in the clinical controversy over the safety of prescribing digoxin
in patients with atrial fibrillation, a secondary analysis of the roughly 18,000-patient ARISTOTLE trial has come down emphatically on the side of avoiding the venerable drug.
Objective: To compare the efficacy of amiodarone and digoxin
for patients who underwent valve-related cardiac surgery and had atrial fibrillation in the first 72 hours post-operatively.
Researchers writing in the European Heart Journal, May 4, analyzed 19 different studies, and found that people taking digoxin
had a 21 percent higher risk of death from any cause compared to people not taking the drug.
I take digoxin
for atrial fibrillation, and a friend told me she recently saw an article saying that it's a very dangerous drug.
Individuals who take the drug digoxin
to treat the irregular and often rapid heartbeat associated with atrial fibrillation (AFib) may be at greater risk of death than individuals who take other medications for the condition, a new study suggests.
Opie suggests that digoxin
, for the indication of HF, would not be passed by regulatory agencies on the basis of present data.
Preparation of Digoxin
solution: The marketed digoxin
ampoules (Sunpharma Ltd.
In vivo experiments showed that single-dose SLE at 500 mg/kg could increase the area under the plasma concentration time curve of digoxin
and vincrisine significantly without affecting terminal elimination half-time.
(Lanoxin[R]) is the only cardiac glycoside approved for use in the U.
Considering her cardiomyopathy and the need for inotropic support, digoxin
was added with an intention to discontinue amiodarone after digoxin
You are probably unaware that I wrote a book, The Nurses are Innocent--The Digoxin
Poisoning Fallacy (Dundurn Press, Toronto), which was published the month following the publication of the Bowal/Horvat article.