We have formulated dimenhydrinate
as chewing gum with acceptable taste and sensory attributes.
Contract awarded for event 3598/2015 dimenhydrinate
solution for injection 50 mg / ml ampoule 1ml
Table 1: Summary of systemic therapeutic alternatives in clinical practice Medication Dose in dialysis Common adverse effects Oral antihistamines Hydroxyzine 10-25 mg po OD-TID Drowsiness, dizziness, dry mouth, weight gain in the long-term Diphenhydramine 25 mg po BID-TID Dimenhydrinate
25-50 mg po BID-TID Loratadine 10 mg po every other day Desloratadine 5 mg po every other day Cetirizine 5 mg po once daily Anti-epileptic Gabapentin 100 mg po post Drowsiness, HD Max: 300mg/day dizziness, fatigue, loss of balance, tremor Pregabalin 25-75 mg po daily Antidepressant 10 mg po BID Sedation, dry mouth, Doxepin urinary retention, constipation, blurred vision, orthostatic hypotension, sexual dysfunction, weight gain
1] Promethazine Motion sickness receptor Cyclizine PINV (dimenhydrinate
and diphenhydramine) Diphenhydramine Acetylcholine Hyoscine Motion sickness muscarinic Cyclizine PONV receptor antagonists Cannabinoid Nabilone (not CINV CB1 receptor currently agonists available in NZ) Corticosteroids Dexamethasone CINV Class Key adverse effects Dopamine [D.
1) Researchers have also reported that 940mg of ginger root duff was more effective than dimenhydrinate
and other antiemetic drugs in a study of 1489 subjects with sea-sickness.
ginger is more effective in preventing motion-sickness than dimenhydrinate
First line medication choice would be meclizine, followed by scopolamine and dimenhydrinate
depending upon symptom presentation.
The sedation consists of oral dimenhydrinate
(Dramamine) 50 mg and IV midazolam 2 mg and IV metoclopramide 10 mg preoperatively in the holding area.
A comparative study with placebo and dimenhydrinate
Many other drugs have been used in treating migraines, including: acetaminophen (alone, or in combination with caffeine and butalbital, aspirin and caffeine, or isometheptene and dichloralphenazone); NSAIDs, including aspirin; chlorpromazine (Thorazine); dimenhydrinate
(Dramamine); diphenhydramine (Benadryl); morphine; meperidine; intranasal butorphanol (Stadol); and corticosteroids.