III], MMA, and dimethylarsinic acid
(DMA), followed by detection by inductively coupled plasma mass spectrometry (Reuter et al.
III]); a second methylation generates dimethylarsinic acid
, pentavalent ([DMA.
In order to determine the individual arsenic species, such as As (III), As (V), monomethylarsonic acid (MMA), dimethylarsinic acid
(DMA), and arsenobetaine (AsB) in a sample, the spectroscopic detector must be coupled with a chromatographic separation technique such as ion chromatography or high performance liquid chromatography.
Two arsenic species, 2-dimethylarsinylethanol (DMAE) and dimethylarsinic acid
(DMAA) were identified from the "open" system decomposition products by using the High Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry (HPLC-ICPMS) technique.
Until recently, the methylation process was thought to be the only detoxification pathway, because two major metabolites, monomethylarsonic acid [MMA(V)] and dimethylarsinic acid
[DMA(V)] are more readily excreted and less acutely toxic than inorganic arsenic (Steinmaus, Yuan, Kalman, Atallah, & Smith, 2005).
The inorganic arsenics can be either methylated (monomethylarsonic acid, MMA) or dimethylarsinic acid
(DMA) in vivo.
Similarly, the characteristic MS/MS spectrum of dimethylarsinic acid
While inorganic arsenite [As(III)] and arsenate [As(V)] are very toxic, monomethylarsonic acid (MMA) and [TABULAR DATA FOR TABLE 1 OMITTED] dimethylarsinic acid
(DMA) are much less so.
41) [SIGMA] As, sum of inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid
The separation of dimethylarsinic acid
, methylarsonous acid, methylarsonic acid, arsenate and dimethylarsinous acid on the Hamilton PRP-X100 anion-exchange column.
methylarsonic acid (MMA)  and dimethylarsinic acid
(DMA), in the body, and these four species [As(III), As(V), MMA, and DMA] can be excreted in urine after exposure to inorganic arsenic.
Humans metabolize inorganic arsenic by a series of methylation reactions, first into methylarsonic acid (MMA) and then into dimethylarsinic acid
(DMA), both of which are excreted in urine.