Gene expression of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine
in the rat.
196] In that instance, the conclusion that the substance dimethylnitrosamine
, a carcinogen, was a human liver poison was based upon acute toxicity studies in rats, inhalation studies in dogs and mice, three sets of case studies in humans (two people each), pathology evidence, some DNA studies, and extensive circumstantial evidence, but no epidemiological studies.
In meat it forms carcinogenic nitrosamines, nitrosopyrrolidine and dimethylnitrosamine
, in the part per billion range (Rubin, 1977).
Additionally, some of the known carcinogens, such as benzo(a)pyrene, benzene, 2-naphthylamine, and dimethylnitrosamine
, are found in higher concentrations in sidestream smoke.
(DMN) -- a known animal carcinogen -- is usually a potent mutagen in the Ames assay.
We are of the view, however, that programs for control of chemical carcinogens must also encompass certain judiciously chosen class 2A or "probable" human carcinogens, such as diesel exhaust, indoor emissions produced by combustion of biomass fuels, and dimethylnitrosamine
, for which there is already strong evidence of carcinogenicity in animal, cellular, or molecular models and limited human data (IARC 2011).
(DMN) is metabolised by DMN-N-demethylase I leading to the generation of carbonium ion that methylates DNA and other macromolecules.
In the present study, we performed dimethylnitrosamine
(DMN)-induced liver fibrosis in rats to assess the benefits of puerarin (PR), which was isolated from Pueraria lobata (Willd.